Influence Exploration of Sperm DNA Damage on IVF Pregnancy Outcome
SUN Bo-lan
ZOU Hong-yan
PENG Nan-ni
Abstract：Objective To investigate the effect of sperm DNA damage on IVF pregnant outcome .Methods Selecting 100 copies of the implementation of IVF sperm as detection object in the hospital from September , 2012 to September , 2013 , according to the test results .On the sperm DNA damage (damage rate was higher than 15%, the injury group (DNA) and normal sperm <15% damage), the effect of IVF outcome was discussed .Results The injury group by statistic showed the sperm acrosin activity , sperm concentration , percentage of normal sperm morphology , sperm motility, good quality embryo rate , fertilization rate of IVF were lower than the normal group , and the difference was statistically significant (P<0.05).Fertilization rate of ICSI was more than that in the normal group , and the difference was statistically significant (P<0.05).The result of the injury group after statistical showed the live birth rate was 30%, and the abortion rate was 10%.The result of the normal group showed that the live birth rate was 50%, and the abortion rate was 10%.There was statistical sig-nificance between two groups (P<0.05).Conclusion Risk prediction of sperm DNA damage detection in a test tube baby can be regar-ded as the effective reference index .The detection rate of sperm DNA damage and DNA damage are suitable for the application program to get smaller or no damage sperm , and has an important role on improving IVF pregnancy outcome .
Keywords：Sperm DNA damageIVFPregnancy outcomeInfluence
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 630-631 )