Exploration of the Relationship Between Homeostasis Model Assessment -B and the Glucose Solution of Hypersensitive 3C-reativeprotrin (Hs-CRP) and Type 2 Diabetic Patient (T2DM) Treatment

JIN Lei; CHANG Xiang-yun

doi:10.3969/j.issn.1004-5775.2014.06.006

Abstract：Objective To discuss the relationship between homeostasis model assessment -B and the glucose solution of hypersensitive 3c-reativeprotrin (hs -crp) and type 2 diabetic patient (t2dm) treatment.Methods Selecting 112 patients with type 2 diabetes. Through Hs-CRP detection of blood glucose and glycosylated hemoglobin , fasting automatic biochemical analyzer (HbA1c) and other indi-cators, they were divided into different groups: HbA1c<7%, HbAlc7%~9%, and HbAlc>9% group.The complications of patients were recorded.Hs-CRP, fasting plasma glucose( FBG ) and HbA1c were detected.Fasting insulin level was detected to measure Homa . Hs-CRP, FBG, BMI, Homa IS and hip level in different groups were compared .Results (1) HbA1c>9%, Hs-CRP and Homa IS groups increased significantly compared with HbAlc <7%and HbAlc7%~9%groups.(2)Homa IS, Hs-CRP and HbA1c had negative relationship.Smoking patients didn′t reach the proportion in blood glucose significant low level .(3)Through regarding Hs-CRP group as the dependent variable , all factors were put into a single factor Logistic regression analysis .It was found that smoking history and combined with 2 or more chronic diseases had significance .Further multivariate Logistic regression analysis showed that smoking and with more than 2 kinds of chronic diseases were risk factors of Hs -CRP.Conclusion (1)Hs-CRP significant increase is related with unsuccessful blood glucose control.This needs improvement schedule .And the smoking history is one of the influencing factors of treatment effect .(2)Hs-CRP can reflect homeostasis model assessment -B.(3) The glucose solution can not be formulated only with patients′fasting insulin, but also with Hs-CRP and Homa IS.(4) There was high correlation between smoking history and T 2DM combined with two kinds chronic diseases and Hs-CRP.This proposes that it is difficult to achieve the goal when diabetes is combined with lots of chronic diseases .