Simultaneous Determination of Three Typical PPCPs in Water by High Performance Liquid Chromatography with Solid Phase Extraction
XU Bingjie
XU Bin
DU Haijie
WANG Tianfeng
QIU Xiuwen
ZHAN Changchao
Abstract：A simultaneous determination method by high performance liquid chromatography with solid phase extraction (SPE) was established and optimized for paracetamol (PCT),iopromide (IOP) and amoxicillin (AMX),which are typical pharmaceuticals and personal care products (PPCPs).The method went as the detection wavelength was 230 nm and the column temperature was 30 ℃,using gradient elution process with methanol/water as mobile phase to achieve separation of target PPCPs.The linearity appeared well that RSD of each pharmaceutical was above 0.998.The limit of detection was 10.2～247.3 μg/L,and the recovery range of standard addition for deionized water samples was 94.97％～102.45％ with R2 range of 0.238％～ 0.756％.The SPE method took HLB as column,sample flow rate of 3 mL/min and methanol of 8 mL as eluant,which received recovery rate of 80.45％～89.70％.Application of this method for effluent of sewage treatment plant in Jiujiang University showed that the concentrations of IOP and AMX were 0.400 μg/L and 19.866 μg/L,respectively.
Keywords：solid phase extractionhigh performance liquid chromatographyPPCPsparacetamoliopromideamoxicillin
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 37-41 )