The impact of sleep quality improvement on quality of life in Parkinson's disease patients

WU Jingjing; XIANG Xiaoping; ZHOU Xiang

doi:10.3969/j.issn.1002-7386.2026.02.016

Abstract：Objective To investigate the impact of sleep quality on quality of life in patients with Parkinson's disease(PD),and to examine the potential mediating roles of fatigue and social isolation,thus providing a theoretical basis for integrated interventions of non-motor symptoms.Methods A prospective controlled trial was conducted,involving 120 patients diagnosed with PD in the outpatient clinic or hospitalization in the Jiangsu Province Hospital from June 2023 to June 2024.They were randomly assigned to the intervention group and the control group(n=60 each).Patients in the intervention group received an 8-week multidimensional intervention,while those in the control group received routine health education.Sleep quality,fatigue,social support,and quality of life were assessed before and after the intervention using the Parkinson's Disease Sleep Scale-2(PDSS-2),Fatigue Severity Scale(FSS),Lubben Social Network Scale(LSNS),and Parkinson's Disease Questionnaire-8(PDQ-8)scales.Group comparisons,correlation analysis,and mediation modeling were performed.Results The intervention group showed significant improvements in sleep quality,fatigue,social support,and quality of life compared to the control group(P<0.05).Sleep quality was positively correlated with fatigue and quality of life,and negatively correlated with social support.Mediation analysis revealed that sleep quality had a direct positive effect on quality of life,which also exerted partial indirect effects through fatigue and social isolation,accounting for 16.04%and 36.92%of the total effect,respectively.Conclusion Sleep disturbance is a key factor affecting quality of life in PD patients.Fatigue and social isolation partially mediate this relationship.Multidimensional interventions can effectively improve non-motor symptoms and enhance overall quality of life.Individualized management and strengthened social support are recommended in clinical practice.