Diagnostic value of IL-17,CCL2 and HBP in bronchoalveolar lavage fluid for pulmonary infection in patients with chronic obstructive pulmonary disease
HUANG Xincheng
YANG Qiuling
HUANG Zhongjie
Abstract：Objective To investigate the diagnostic value of chemokine ligand 2(CCL2),interleukin-17(IL-17)and heparin-binding protein(HBP)levels in bronchoalveolar lavage fluid(BALF)for pulmonary infection in patients with chronic obstructive pulmonary disease(COPD).Methods A total of 109 COPD patients admitted to the respiratory department of our hospital from December 2021 to December 2023 were enrolled,and they were divided into infected group(n=35)and non-infected group(n=74)according to presence or absence of pulmonary infection.Clinical data,conventional infection markers including high sensitive C-reactive protein(hs-CRP)level,procalcitonin(PCT),serum amyloid A(SAA),and IL-17,CCL2 and HBP levels in BALF were compared between groups,and the correlation between IL-17,CCL2 and HBP in BALF and conventional infection markers was analyzed.Receiver operating characteristic(ROC)curve was plotted to evaluate the diagnostic value of IL-17,CCL2,HBP and conventional infection markers in BALF for pulmonary infection in COPD patients.In addition,net reclassification improvement(NRI),and integrated discrimination improvement(IDI)were performed to verify the effect of the combined diagnosis of IL-17,CCL2 and HBP in BALF versus single diagnosis or conventional infection markers.Results The levels of hs-CRP,PCT,SAA,IL-17,CCL2 and HBP in BALF in infected group were significantly higher than those in non-infected group(P<0.05).Pearson correlation analysis showed that IL-17,CCL2 and HBP in BALF of COPD patients were significantly positively correlated with hs-CRP,PCT and SAA(P<0.05).The area under the ROC curve(AUC)of the combination of IL-17,CCL2 and HBP was significantly higher than that of single indicator(0.931 vs 0.821 vs 0.833 vs 0.837),with the optimum sensitivity and specificity of 89.78%and 93.57%,respectively.The AUC of the combination of hs-CRP,PCT and SAA was significantly higher than that of single indicator(0.915 vs 0.813 vs 0.779 vs 0.827),with the optimum sensitivity and specificity of 80.00%and 89.19%,respectively.Compared with a single index,IL-17+CCL2+HBP and hs-CRP+PCT+SAA significantly improved the diagnostic ability of pulmonary infection in COPD patients,especially IL-17+CCL2+HBP.NRI and IDI were 0.736(0.581-0.927)and 0.075(0.052-0.131),respectively.Conclusion The levels of IL-17,CCL2 and HBP in BALF of COPD patients with pulmonary infection are significantly increased,and the combined detection of the three can improve the diagnostic efficiency.Therefore,the levels of IL-17,CCL2 and HBP should be monitored clinically in order to take timely treatment measures and improve the prognosis of patients.
Keywords：chronic obstructive pulmonary diseasebronchoalveolar lavage fluidinterleukin-17chemokine ligand 2heparin-binding proteinpulmonary infection
Publication Date：2026-02-26
Online Publishing Date：2026-03-23(First online date of this platform, not the publication date of the document)
Pages：5( 227-231 )