Effect and adverse effects of recombinant human growth hormone in children with idiopathic short stature managed by age-appropriate psychosomatic nursing
LEI Xing
QIAO Hongyu
GOU Yingfang
Abstract：Objective To investigate the clinical efficacy of age-appropriate psychosomatic nursing in children with idiopathic short stature(ISS)who are treated with recombinant human growth hormone(rh-GH),and the adverse effects.Methods A total of 96 children with ISS who were admitted to the Department of Pediatrics from February 2022 to February 2024 were selected as the study objects.They were randomly divided into two groups according to random number table method,with 48 cases per group.Children in the control group were treated with rh-GH alone,and those in the experimental group were treated with age-appropriate psychosomatic nursing plus rh-GH.The treatment time was 12 months.After the intervention,25 hydroxy-vitamin D3[25-(OH)D3],insulin-like growth factor 1(IGF-1),growth and development indicators,clinical efficacy and adverse events were compared.Results The total effective rate of the experimental group was significantly higher than that of the control group(P<0.05).The height and growth rate of the experimental group were significantly higher than those of the control group after intervention(P<0.05).Expression levels of 25-(OH)D3 and IGF-1 in the experimental group were significantly higher than those in the control group after intervention(P<0.05).Expression levels of baseline bone-specific alkaline phosphatase(BSAP)and osteocalcin(OC)in the experimental group were significantly higher than those in the control group after intervention(P<0.05).There was no significant difference in the total incidence of adverse events between groups(P>0.05).Conclusion The application of age-appropriate psychosomatic nursing in rh-GH treatment of ISS has good clinical efficacy,which can promote the growth and development of ISS children,improve the growth rate of the body,correct the abnormal expression levels of 25-(OH)D3 and IGF-1,improve bone metabolism,and have high safety.
Keywords：age-appropriate psychosomatic nursingidiopathic short staturerecombinant human growth hormone25 hydroxyvitamin D3insulin-like growth factor 1adverse events
Publication Date：2026-01-26
Online Publishing Date：2026-03-17(First online date of this platform, not the publication date of the document)
Pages：4( 157-160 )