Advances of ferroptosis induced by the Nrf2-HO-1/GPX4 axis in Staphylococcus aureus infection
ZHANG Xuan
CHEN Quanxin
LI Junliang
Abstract：Infection remains a common and difficult-to-treat disease in clinical practice.Although the pathogenesis of infection has been studied for many years,it is still not well understood.Staphylococcus aureus(SA)is one of the most prevalent pathogens responsible for various infections,with its resistance escalating due to the widespread use of antibiotics.Ferroptosis,an emerging programmed cell death mechanism,significantly influences the progression of infections,neurological conditions,and liver ailments.Recent evidence shows that nuclear factor E2-related factor 2(Nrf2)is not only of significance in preserving oxidative equilibrium within tissue cells,but also in regulating ferroptosis.Nrf2 governs the expressions of downstream genes,such as heme oxygenase 1(HO-1)and glutathione peroxidase 4(GPX4),thereby averting cellular ferroptosis and subsequently impacting inflammation dynamics.Through summarizing existing literatures,this review analyzed the prospectives of ferroptosis change after SA infection,potential regulation of Fe iron,ferroptosis involved in the pathogenesis of SA infection,and ferroptosis regulated by the Nrf2-HO-1/GPX4 axis.It provided theoretical references for illustrating the pathogenesis of SA infection,and treatment of SA Infection by targeting the Nrf2-HO-1/GPX4 axis.Moreover,this review offered new ideas and directions in the design and synthesis of antimicrobial drugs.
Keywords：Staphylococcus aureusferroptosisNrf2-HO-1/GPX4
Publication Date：2026-01-26
Online Publishing Date：2026-03-17(First online date of this platform, not the publication date of the document)
Pages：6( 117-122 )