The impacts of individualized enteral nutrition therapy under the concept of enhanced recovery after surgery on postoperative nutritional status and immune function of laryngeal cancer patients
DING Qiuwen
CHEN Xi
LU Zhaoyi
Abstract：Objective To explore the impacts of individualized enteral nutrition therapy(ET)under the concept of enhanced recovery after surgery(ERAS)on the postoperative nutritional status and immune function of laryngeal cancer patients.Methods From July 2022 to August 2024,102 patients with laryngeal cancer were randomly assigned into the routine group(n=51,receiving routine care)and nutritional intervention group(n=51,receiving individualized ET intervention under the ERAS concept based on the routine group).The nutritional status(albumin[Alb],prealbumin[PA]),immune function(immunoglobulin[Ig]A,IgG,CD+3,CD+4),Piper Fatigue Scale(PFS)score,levels of inflammatory factors(C-reactive protein[CRP],interleukin-6[IL-6]),incidence of postoperative complications,and length of hospital stay were compared between the two groups.Results One week after surgery,the levels of Alb,PA,IgA,IgG,CD+3,and CD+4 in the nutritional intervention group were significantly higher than those on admission(P<0.05),while the levels of Alb,PA,IgA,IgG,CD+3,and CD+4 in the routine group were significantly lower than those on admission(P<0.05).Alb,PA,IgA,IgG,CD+3,and CD+4 levels in the nutritional intervention group were significantly higher than those in the routine group(P<0.05).One week after surgery,the PFS score of the nutritional intervention group was significantly lower than that on admission(P<0.05),while the PFS score of the routine group was significantly higher than that on admission(P<0.05),The PFS score of the nutritional intervention group was significantly lower than that of the conventional group(P<0.05).One week after surgery,the levels of CRP and IL-6 in both groups were significantly higher than those on admission(P<0.05),but the levels of both inflammatory factors in the nutritional intervention group were significantly lower than those in the routine group(P<0.05).The incidence of postoperative complications in the nutritional intervention group was significantly lower than the routine group(P<0.05),and the postoperative hospital stay was significantly shorter than that in the routine group(P<0.05).Conclusion Individualized ET under the ERAS concept can improve postoperative nutritional status and immune function and cancer-related fatigue in laryngeal cancer patients,accelerate inflammation resolution,reduce the incidence of complications,and shorten postoperative recovery time.
Keywords：enhanced recovery after surgeryindividualized enteral nutrition therapylaryngeal cancerimmune function
Publication Date：2026-01-26
Online Publishing Date：2026-03-17(First online date of this platform, not the publication date of the document)
Pages：4( 70-73 )