Effects of oral drip of multi-oil fat emulsion on gut microbiota and neurointelligence development of very low birth weight premature infants
ZHANG Haijun
SUN Xiaohui
ZHANG Yingcui
Abstract：Objective To observe and analyze the effects of oral drip of multi-oil fat emulsion on gut microbiota and neurointelligence development of very low birth weight premature infants.Methods Eighty patients with MPP who were treated in Dingxi People's Hospital from October 2023 to September 2024 were included as the study subjects.Eighty very low birth weight preterm infants were divided into two groups using a random number table:40 in the SMOF(soybean oil,medium-chain triglycerides,olive oil,and fish oil)group and 40 in the medium-chain triglycerides/lon-chain triglycerides(MCT/LCT)group.After the completion of the treatment,the rehabilitation indexes,liver function,blood lipid index level,the Preterm Infant Oral Feeding Readiness Assessment(PIOFRA)score,gut microbiota,and neurointelligence development of the two groups were compared.Results The muscle tone recovery time,total enteral nutrition time,fetal excretion time and hospital stay time of SMOF group were significantly shorter than the MCT/LCT group(P<0.05).After treatment,aspartate aminotransferase(AST),albumin(ALB)and globulin levels in the SMOF group were significantly higher than the MCT/LCT group,and gamma-glutamyl transferase(γ-GT),total bile acids(TBA),direct bilirubin(DBIL),total bilirubin(TBIL),alanine aminotransferase(ALT),alkaline phosphatase(ALP),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),triglycerides(TG)and total cholesterol(TC)levels were significantly lower than the MCT/LCT group(P<0.05).After additional treatment,the ability to maintain physiological stability during feeding,preterm state,swallowing ability,sucking ability,passive muscle tone,coarse motor tone,active muscle tone,fine motor score,psychomotor development index,intelligence development index,Lactobacillus and Bifidobacterium in SMOF group were all significantly higher than the MCT/LCT group after treatment.The Escherichia coli and incidences of complications were significantly lower than the MCT/LCT group(P<0.05).Conclusion SMOF has good tolerance and safety for very low birth weight preterm infants.Compared with MCT/LCT,oral drip of multi-oil fat emulsion can promote the neurointelligent development of very low birth weight premature infants,and the use effect is better.
Keywords：multi-oil fat emulsionvery low birth weight premature infantsintestinal floraneurointelligence development
Publication Date：2026-01-26
Online Publishing Date：2026-03-17(First online date of this platform, not the publication date of the document)
Pages：5( 65-69 )