Effects of low-dose nifedipine combined with vitamin D on hemorheology and intrauterine growth restriction in patients with gestational hypertension
ZHANG Fanfan
BU Wenmei
LI Na
Abstract：Objective To explore the clinical efficacy of low-dose nifedipine combined with vitamin D in treating gestational hypertension(GH),and to explore their influence on intrauterine growth restriction and hemorheology.Methods Eighty-five GH patients admitted from January 2023 to May 2024 were selected.They were grouped according to different treatments,including 43 cases in the control group and 42 cases in the combined group.Baseline data,hemorheology,coagulation function index,oxidative stress index,umbilical artery flow index,vascular elasticity index,endothelial index,thromboelastography(TEG)parameters,psychological resilience scores,adverse pregnancy outcomes,and clinical efficacy were compared between groups.Results Compared with pre-treatment values,malondialdehyde(MDA),k value,brachial-ankle pulse wave velocity(ba-PWV),resistance index(RI),whole blood low shear viscosity,pulsatility index(PI),Ep,D-dimer(D-D),whole blood high shear viscosity,Endothelin-1(ET-1),systolic/diastolic(S/D),fibrillation(FIB),plasma viscosity,lipid peroxidation(LPO)and soluble vascular cell adhesion molecule-1(sVCAM-1)after the treatment were significantly lower,and R value,resilience score,nitric oxide(NO),thrombin time(TT),optimistic score,α-angle,superoxide dismutase(SOD),prothrombin time(PT),strength score,MA and AC were significantly higher(P<0.05).Compared with the control group,patients in the study group had significantly lower K,whole blood high shear viscosity,ba-PWV,PI,D-D,MDA,ET-1,whole blood low shear viscosity,S/D,Ep,FIB,plasma viscosity,LPO,RI,sVCAM-1 and incidence of poor pregnancy outcome,but higher R,NO,resilience score,TT,α-angle,SOD,optimistic score,PT,MA,strength score,AC and overall clinical efficacy rate(P<0.05).Conclusion Low-dose nifedipine combined with vitamin D in treating GH can significantly reduce the level of hemorheology,reduce the incidence of fetal functional growth restriction,improve vascular endothelial function,oxidative stress,stable uterine arterial blood flow and elevate clinical efficacy.
Keywords：low-dose nifedipinevitamin Dgestational hypertensionhemorheologyintrauterine growth restriction
Publication Date：2026-01-26
Online Publishing Date：2026-03-17(First online date of this platform, not the publication date of the document)
Pages：5( 44-48 )