Therapeutic effect of semaglutide on depression in patients with type 2 diabetes mellitus combined with ischemic stroke

WANG Caining; YANG Meiliu; YU Wu

doi:10.3969/j.issn.1002-7386.2025.12.027

Abstract：Objective To investigate the effects of semaglutide on blood glucose,blood lipids and mental status in type 2 diabetes mellitus(T2DM)patients with ischemic stroke and depression.Methods A total of 100 T2DM patients with ischemic stroke and depression admitted to the Department of Endocrinology in Kailuan General Hospital from January 2022 to December 2023 were selected and randomly divided into the observation group(n=50)and control group(n=50)by the random number method.Patients in the observation group were treated with metformin plus semiglutide,and those in the control group were treated with metformin plus insulin glargine injection.The dosage was adjusted according to the patient's blood sugar level.Gender,age,course of disease,fasting blood glucose(FBG),hemoglobin A1c(HbA1c),total cholesterol(TC),triglyceride(TG)level,low-density lipoprotein cholesterol(LDL-C),the Hamilton Depression Rating Scale(HAMD)score,body mass index(BMI)and insulin resistance index(HOMA-IR)were recorded before treatment and 3 and 6 months after treatment.Results After 3 months of treatment,FBG,HOMA-IR,HbA1c and HAMD scores in both groups were significantly reduced than pre-treatment values(P＜0.05).The HAMD scores of the patients treated with semaglutide were significantly lower than those treated with insulin glargine.The levels of BMI,TC,TG and LDL-C were also significantly reduced in patients treated with semaglutide(P＜0.05),which were not significantly changed in patients treated with insulin glargine.After 6 months of treatment,HbA1c and HAMD scores were significantly lower in patients treated with semaglutide than those treated with insulin glargine(P＜0.05).Conclusion For T2DM patients with ischemic stroke and depression,both semaglutide and insulin glargine can reduce the blood sugar of patients.Semaglutide,however,can better reduce the body weight and lipid levels,and also have a significant improvement in mental state.