Influence of stepwise synergistic nutritional management combined with Xingnaojing Injection on the effect of neurological function recovery in patients with cerebral hemorrhage

ZHOU Jing; ZHANG Huajian; LU Yang

doi:10.3969/j.issn.1002-7386.2025.12.023

Abstract：Objective To explore the effect of stepwise synergistic nutritional management combined with Xingnaojing Injection on neurological function recovery of patients with cerebral hemorrhage.Methods A total of 112 patients with cerebral hemorrhage treated between March 2022 and December 2023 were retrospectively studied as research subjects.They were divided into the experimental group and the control group according to the different treatment methods.Patients in the control group(n=56)were given the internal medicine conservative treatment and routine nutritional intervention,and the intracranial hypertension was treated with mannitol to lower the intracranial pressure.Those in the experimental group(n=56)were treated with stepwise synergistic nutritional management combined with Xingnaojing Injection on the basis of the treatment program of the control group.The nutritional status,neurological function and neurological function influencing factors,as well as stress indicators and clinical efficacy of the two groups were compared.Results Transferrin(TF),albumin(ALB),and prealbumin(PA)before treatment were comparable between groups(P＞0.05),which were elevated at varying degrees in both groups after treatment,and significantly pronounced in the experimental group than the control group(P＜0.05).The National Institutes of Health Stroke Scale(NIHSS)and Glasgow Coma Scale(GCS)scores before treatment were comparable between groups(P＞0.05).NIHSS score significantly decreased,while the GCS score significantly increased after treatment,which were significantly pronounced in the experimental group than the control group(P＜0.05).The neuron-specific enolase(NSE),plasma S100,matrix metalloproteinase 9(MMP-9)and myelin basic protein(MBP)were comparable between groups(P＞0.05),which were significantly improved in both groups after treatment,and significantly pronounced in the experimental group than the control group(P＜0.05).Oxidative stress before treatment was comparable between groups(P＞0.05).The superoxide dismutase(SOD)and AngⅡ were significantly elevated,and malondialdehyde(MDA)was significantly reduced in both groups after treatment,which were significantly pronounced in the experimental group than the control group(P＜0.05).The total effective rate was significantly higher in the experimental group than the control group(85.7％vs 66.1％,P＜0.05).Conclusion Stepwise synergistic nutritional management combined with Xingnaojing Injection effectively improves the nutritional status,alleviates neurological damage,adjusts stress responses,and enhance clinical therapeutic effects on cerebral hemorrhage.