Correlation analysis of risk factors between severe stenosis of the cerebral artery versus the coronary artery

YAN Mengfan; LIU Xiaopeng; LIU Suyun

doi:10.3969/j.issn.1002-7386.2025.12.010

Abstract：Objective To explore the differences in exposure factors and exposure levels in patients with coronary artery severe stenosis versus cerebral artery severe stenosis,and to analyze the relevant risk factors,thus providing a theoretical basis for the early prevention of cardiovascular and cerebrovascular diseases.Methods Totally 120 patients with severe stenosis of the coronary and/or cerebral arteries from July 2021 to July 2023 were included.They were divided into the cerebral artery stenosis group,coronary artery stenosis group,and cerebrocardiac artery stenosis group based on the location of the affected arteries.Clinical data and laboratory indicators of the three groups were collected.Independent risk factors for severe arterial stenosis were identified using a logistic regression model.Results There was a significant difference in the correlation between gender composition and distribution of severe arterial stenosis among the three groups(x2=10.015,P＜0.01).The levels of apolipoprotein A1(ApoA1),high-density lipoprotein cholesterol(HDL-C),and glycosylated hemoglobin(HbA1c)in the cerebral artery stenosis group were significantly higher than the cerebrocardiac artery stenosis group(P＜0.05).The levels of total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and apolipoprotein B(ApoB)in the cerebral artery stenosis group were significantly higher than the coronary artery stenosis group(P＜0.05).A multivariate logistic regression analysis was conducted with the coronary artery stenosis group as the control group.The results showed that body mass index(BMI)had a significant impact on cerebral artery stenosis(OR=0.825,P=0.035).The number of patients with both intracranial and extracranial artery stenosis in the cerebrocardiac artery stenosis group was significantly higher than the cerebral artery stenosis group(x2=7.132,P＜0.05).Conclusion Male are more prone to severe stenosis of only coronary artery,and both coronary and cerebral arteries.Individuals with high BMI are more prone to severe stenosis of only coronary artery.Individuals with higher levels of ApoA1,HDL-C,and HbA1c are more prone to severe stenosis of only cerebral artery.Individuals with higher levels of TC,LDL-C,and ApoB are more prone to developing only cerebral artery stenosis.Among patients with severe stenosis of both coronary and cerebral arteries,those with stenosis of both intracranial and extracranial arteries are significantly higher than the stenosis of only cerebral artery.