Evaluation of the effect of meropenem on cerebrospinal fluid penetration in meningitis patients after neurosurgery
SHEN Yanping
BAI Jinqiao
Abstract：Objective To investigate the effect of meropenem on cerebrospinal fluid(CSF)penetration in meningitis patients after neurosurgery.Methods A total of 120 meningitis patients treated from 2021 to 2024 were compared.Meropenem was administered intravenously according to the schedule of 2g/8h,1g/8h,1g/6h.During the fourth administration,both blood and CSF samples were taken at a predetermined time point.The content of meropenem was determined by high-performance liquid chromatography(HPLC).Results The peak concentrations of meropenem in blood and cerebrospinal fluid were(43.2±5.3)and(2.4±0.3)mg/L in the 2g/8h group,(28.9±2.7)and(1.2±0.2)mg/L in the 1g/8h group,and(31.5±3.4)and(1.6±0.2)mg/L in the 1g/6h group,respectively.The maximum CSF permeability was 17.6％±7.3％,14.3％±1.7％and 30.9％±24.2％,respectively.Conclusion CSF permeability of meropenem at 1g/6h and 2g/8h is higher than 1g/8h.A higher dose of meropenem given in a shorter dosing interval is more effective in removing pathogens.
Keywords：neurosurgerymeningitismeropenemcerebrospinal fluid penetration
Publication Date：2025-11-26
Online Publishing Date：2025-12-12(First online date of this platform, not the publication date of the document)
Pages：4( 1815-1818 )