Effects of dapagliflozin on the left atrial function and prognosis in patients with paroxysmal atrial fibrillation complicated with type 2 diabetes mellitus
YANG Ying
SONG Da
CHEN Jianjun
Abstract：Objective To observe the effects of dapagliflozin on the left atrial function and prognosis in patients with paroxysmal atrial fibrillation(AF)complicated with type 2 diabetes mellitus(T2DM).Methods A total of 59 T2DM patients with paroxysmal AF who were treated in Baoding First Central Hospital from December 2021 to June 2023 were randomly divided into two groups:the dapagliflozin treatment group(n=29)and the placebo group(n=30).N-terminal prohormone of brain natriuretic peptide(NT-proBNP),high-sensitivity C-reactive protein(hs-CRP),body mass index(BMI),uric acid,and cardiac ultrasound indicators like left atrial diameter(LAD),right atrial diameter(RAD),left ventricular ejection fraction(LVEF),left atrial ejection fraction(LAEF),strain(S％),systolic strain rate(SRs),diastolic strain rate(SRe),and atrial systolic strain rate(SRa)were observed on the first day and three months later in both groups.Results There were no significant differences in general condition,biochemical indicators,and ultrasound indicators between the two groups of patients at baseline(P＞0.05).After 3 months of treatment,the levels of NT-ProBNP,BMI,hs-CRP,and uric acid in the treatment group were significantly lower than the control group(P＜0.05).In addition,the number of episodes and duration of AF in the treatment group were also significantly better than the control group(P＜0.05).As well,the ultrasound indicators,E peak,SRa,and S％in the treatment group were significantly higher than those in the control group(P＜0.05).In the intra group comparisons,the levels of hs-CRP,BMI,uric acid,and NTPro-BNP in the treatment group were significantly lower compared with those before treatment(P＜0.05).The ultrasound indicators LAD and RAD significantly decreased compared with those before treatment(P＜0.05).The E peak,S％,SRa,LAEF and LVEF significantly increased compared with those before treatment(P＜0.05).These changes were not found in the control group.Conclusion Dapagliflozin treatment can improve BMI,inflammation level,atrial remodeling,left atrial function and left ventricular function in patients with paroxysmal AF complicated with T2DM,thereby reducing the onset and duration of AF,and improving the quality of life and prognosis.
Keywords：paroxysmal atrial fibrillationtype 2 diabetes mellitusdapagliflozinatrial function
Publication Date：2025-10-26
Online Publishing Date：2025-11-19(First online date of this platform, not the publication date of the document)
Pages：5( 1666-1670 )