Effect and prognosis analysis of ulinastatin combined with 1-hour clustered intervention in sepsis

WANG Wei; SHI Liang

doi:10.3969/j.issn.1002-7386.2025.08.020

Abstract：Objective To investigate the effect of ulinastatin combined with 1-hour clustered intervention in sepsis,and to analyze the influencing factors for the prognosis.Methods A total of 75 patients with sepsis diagnosed and treated in our hospital from June 2021 to June 2023 were randomly divided into two groups,including 38 cases in the control group and 37 cases in the observation group.Patients in the control group were given ulinastatin combined with conventional clustered intervention,and those in the observation group were given ulinastatin combined with 1-hour clustered intervention.Procalcitonin(PCT),C-reactive protein(CRP),Acute Physiology and Chronic Health status Scoring System Ⅱ(APACHEⅡ)scores,Sequential Organ Failure Assessment(SOFA)scores of the two groups were compared before and after 7d of treatment.Clinical therapeutic efficacy,length of stay in the intensive care unit(ICU),total length of stay,hospitalization cost,and 28-day mortality were analyzed.Risk factors for the mortality were screened.Results After 7 days of treatment,PCT and CRP in both groups were significantly reduced than pre-treatment values(P＜0.05),which were significantly lower in the observation group than the control group(P＜0.05).After 7 days of treatment,the APACHE Ⅱ and SOFA scores in both groups were significantly reduced than pre-treatment values(P＜0.05),which were significantly lower in the observation group than the control group(P＜0.05).The clinical curative effect of the observation group was significantly better than that of the control group(P＜0.05),and the total effective rate of the observation group was significantly higher than that of the control group(83.78％vs 60.53％,P＜0.05).The length of stay in the ICU and total length of hospital stay in the observation group were significantly shorter than those of the control group(P＜0.05),and the hospitalization cost and 28-day mortality in the observation group were significantly lower than those of the control group(P＜0.05).Univariate analysis showed significant differences in the age,septic shock,prothrombin time(PT),PCT,lactic acid,SOFA score and APACHE Ⅱ score between the death group and the survival group(P＜0.05).Binary Logistic regression analysis showed that age ≥ 60 years and high SOFA were the risk factors for death(P＜0.05).Conclusion Ulinastatin combined with 1-hour clustered intervention in sepsis patients can effectively reduce inflammatory factors,alleviate the condition,improve the therapeutic effect and shorten the length of hospital stay.The 28-day mortality in sepsis patients is associated with age ≥60 years and high SOFA.