Value of ultrasound-guided needle biopsy combined with serum ADAM12,SKP2 and TFF1 in the diagnosis of breast cancer
ZHANG Huixia
LI Yinxia
Abstract：Objective To investigate the diagnostic value of ultrasound-guided needle biopsy combined with serum disintegrin and metalloproteinase-12(ADAM12),S-phase kinase-associated protein-2(SKP2),and trefoil factor family 1(TFF1)levels in breast cancer.Methods A total of 110 suspected breast cancer patients in the Second Affiliated Hospital of Naval Medical University from January 2022 to November 2023 were selected and divided into breast cancer group(n=70)and breast benign lesion group(n=40)with the postoperative pathological diagnosis as the gold standard.The clinical data,preoperative ultrasound-guided puncture biopsy results,serum levels of ADAM12,SKP2,and TFF1,and conventional tumor markers(cancer antigen 125[CA125]and carcinoembryonic antigen[CEA])were compared between the two groups.Serum ADAM12,SKP2 and TFF1 levels of patients with different pathological characteristics of breast cancer were compared.The correlation between serum ADAM12,SKP2 and TFF1 levels and pathological characteristics of breast cancer was analyzed.The value of ultrasound-guided biopsy,serum ADAM12,SKP2 and TFF1 alone and in combination in the diagnosis of breast cancer was analyzed.Results Serum ADAM12,SKP2 and TFF1,CA125 and CEA in breast cancer group were significantly higher than those of benign breast disease group(P＜0.05).Among 110 suspected breast cancer patients,66 positive and 44 negative breast cancer were detected by preoperative ultrasound-guided biopsy,of which 64 were true positive and 38 were true negative.Serum ADAM12,SKP2 and TFF1 levels in patients with lymph node metastasis in breast cancer group were significantly higher than those without metastasis,and serum ADAM12,SKP2 and TFF1 levels in stage Ⅲ-Ⅳ breast cancer patients were significantly higher than those of stage Ⅰ-Ⅱ patients(P＜0.05).Serum ADAM12,SKP2 and TFF1 levels were positively correlated with lymph node metastasis and clinical stage of breast cancer(P＜0.05).The area under the curve(AUC)of ultrasound-guided biopsy,serum ADAM12,SKP2 and TFF1,CA125 and CEA in the diagnosis of breast cancer was 0.815,0.744,0.753,0.751,0.746 and 0.757,respectively.The AUC of ultrasound-guided biopsy combined with serum ADAM12,SKP2 and TFF1 in the diagnosis of breast cancer was 0.953,which was significantly higher than that of ultrasound-guided biopsy combined with serum ADAM12,SKP2 and TFF1 alone(P＜0.05).Conclusion Ultrasound-guided needle biopsy combined with serum ADAM12,SKP2 and TFF1 can significantly improve the diagnostic value of breast cancer.
Keywords：breast cancerultrasound-guided puncture biopsydisintegrin and metalloproteinase-12S-phase kinase-associated protein-2trefoil factor family 1diagnosis
Publication Date：2025-08-26
Online Publishing Date：2025-09-12(First online date of this platform, not the publication date of the document)
Pages：5( 1258-1262 )