Effect of infusion of fresh frozen plasma and red blood cell on coagulation function during cardiac surgery
ZHOU Li
WANG Xu
NIU Cenyue
Abstract：Objective To analyze the effects of infusing fresh frozen plasma(FFP)and packed red blood cell suspension(PRBC)on coagulation function during cardiac surgery.Methods A total of 110 patients with cardiac operation and intraoperative blood transfusion from June 2021 to June 2023 were selected.They were divided into three groups according to different transfusion methods,namely experimental group(FFP∶PRBC=1∶1,n=40),control A group(FFP∶PRBC=1∶2,n=36),and control B group(FFP∶PRBC=1∶3,n=34).Coagulation function(fibrinogen[FIB],activated partial thromboplastin time[APTT],thrombin time[TT],prothrombin time[PT]),electrolyte balance indexes,total incidence of transfusion complications,length of hospital stay,and mortality of the three groups were compared.Results The FIB of the experimental group was significantly higher than that of control group A and control group B after blood transfusion(P＜0.05).After blood transfusion,the APTT,TT and PT of the experimental group were significantly lower than those of control group A and control group B(P＜0.05),and the FIB,APTT,TT and PT of control group A and control group B were comparable after blood transfusion(P＞0.05).After blood transfusion,Na+and Ca2+in the experimental group were significantly lower than those in control group A and control group B(P＜0.05),and K+in the experimental group was significantly higher than that in control group A and control group B(P＜0.05).After blood transfusion,Na+,Ca2+and K+in control group A and control group B were comparable(P＞0.05).The total incidence of blood transfusion complications in the experimental group(2.50％)was comparable with that in control group A(5.56％)and control group B(5.88％)(P＞0.05).The hospital stay and mortality(0)of the experimental group were comparable with those of control group A(2.78％)and control group B(2.94％)(P＞0.05).Conclusion In cardiac surgery,infusion of FFP∶PRBC at 1∶1 can effectively improve coagulation function,maintain electrolyte balance,and does not increase the risk of complications and mortality.It is safe and effective.
Keywords：heart surgeryfresh frozen plasmapacked red blood cell suspensioncoagulation function
Publication Date：2025-07-26
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1135-1137,1142 )