Effect of an early assessment of inflammatory markers by the ultrafast pulse wave velocity on the arterial elasticity in patients with type 2 diabetes mellitus
LIU Fen
ZONG Meinan
WANG Yi
Abstract：Objective To compare the changes in the carotid artery elasticity between patients with type 2 diabetes mellitus(T2DM)and healthy people by the ultrafast pulse wave velocity(UFPWV),and to evaluate the correlation between inflammatory markers and carotid artery elasticity.Methods Sixty T2DM patients without carotid intima-media thickening and plaque formation(study group)and 40 healthy individuals receiving physical examinations(control group),who admitted in the Second Hospital of Hebei Medical University from December 2021 to December 2022 were enrolled.The baseline date,biochemical indicators,inflammatory markers,carotid intima-media thickness(cIMT),and pulse wave velocity(carotid pulse wave velocity at the beginning[PWVBS]and end[PWVES]of systole)were included as comparators.The correlation between each indicator and PWV was identified.Results Patients in the study group had significantly higher cIMT,PWVBS,PWVES,and inflammatory markers high-sensitivity C-reactive protein(hsCRP),neutrophil-to-lymphocyte ratio(NLR),and platelet-to-lymphocyte ratio(PLR),and lower lymphocyte-to-monocyte ratio(LMR)than those of the control group(P＜0.05).PWVBS,PWVES,cIMT were linearly positively correlated with hsCRP,NLR,PLR,and linearly negatively correlated with LMR(P＜0.05).Inflammatory markers(hsCRP,NLR,PLR,and LMR)were the independent influencing factors for the PWV.Conclusion UFPWV can early identify the increase of carotid stiffness in T2DM patients and assess the risk of carotid atherosclerosis(CAS).The rise of inflammatory markers suggests that the occurrence and development of AS should be alerted in clinical practice.Assessment of the above indicators is expected to early identify the occurrence and development of high-risk patients with AS from both micro and macro perspectives,guide treatment,and improve the prognosis of T2DM patients.
Keywords：ultrafast pulse wave velocityinflammatory markerstype 2 diabetes mellitusatherosclerosiscarotid elasticity
Publication Date：2025-07-26
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1099-1103 )