Correlation of the expression of serum S100A12,human beta-defensin,25-hydroxyvitamin D with clinical outcome of preterm infants with necrotizing enterocolitis

FENG Ruqing; MA Yuanyuan; LI Yali

doi:10.3969/j.issn.1002-7386.2025.06.018

Abstract：Objective To study the correlation of the expression of serum S100A12,human beta-defensin(HBD),and 25-hydroxy vitamin D(25OHD)with clinical prognosis in premature infants with necrotizing enterocolitis(NEC).Methods From September 2022 to September 2023,200 premature infants born in the obstetrics department and admitted to the neonatology department within 2 h of birth in Zhangjiakou Maternal and Child Health Hospital were selected as the research subjects.There were 94 cases of NEC(observation group)and 106 cases of healthy(control group).Premature infants with NEC were divided into a good prognosis group(n=61)and a poor prognosis group(n=33)after targeted treatment.Serum S100A12,HBD,25OHD levels were compared between groups.Results Compared with those of healthy preterm infants,the preterm infants with NEC had significantly higher level of S100A12,and lower levels of HBD-1,HBD-2,and 25 OHD(P＜0.05).Compared with those of NEC children with the good prognosis,the NEC children with the poor prognosis presented significantly higher level of S100A12,and lower levels of HBD-1,HBD-2,and 25OHD(P＜0.05).The multivariate Logistic analysis revealed that maternal age,body weight,the levels of S100A12,HBD-1,HBD-2,25OHD,oxygen duration,gestational age,presence or absence of blood transfusion and neonatal asphyxia were all factors affecting the prognosis of the preterm infants with NSC(P＜0.05).The receiver operator characteristic(ROC)results showed that the combined detection of S100A12,HBD,and 25OHD for NEC in premature infants had higher sensitivity and specificity in prognosis compared to their single detection(P＜0.05).Conclusion The higher serum S100A12 and lower HBD-1,HBD-2 and 25OHD are found in preterm infants with NEC compared to those of healthy,which has a great association with their clinical prognosis.It is suggested that more attention should be paid to the serum levels of S100A12,HBD,and 25OHD in the pediatric patients,aim to make early diagnosis and improve their prognosis.