Effect of bronchoscopic lavage combined with methylprednisolone sodium succinate in patients with refractory mycoplasma pneumoniae pneumonia
XU Xuewei
LI Chao
YU Ying
Abstract：Objective To study the effect of bronchoscopic lavage combined with methylprednisolone sodium succinate in adult patients with refractory mycoplasma pneumoniae pneumonia(RMPP),aiming to find a safe and effective therapeutic solution.Methods The subjects of this study included 114 patients with RMPP who admitted to the First Affiliated Hospital of Xinjiang Medical University(January 2022-February 2023).They were divided into the control group(n=57)and observation group(n=57)by a random number table.All patients were managed by routine treatments and methylprednisolone sodium succinate,those in the observation group additionally bronchoscopic lavage.The changes in serum inflammatory factors,immune function,pulmonary ventilation level,and chest-lung compliance were compared between groups before and after treatment.Results After treatment,the levels of C-reactive protein(CRP),procalcitonin(PCT),tumor necrosis factor-α(TNF-α)were significantly lower in both groups than those before treatment,and the decreases in the observation group were more pronounced(P＜0.05).The significantly higher CD4+,CD4+/CD8+,and lower CD8+were found in the both groups than those before treatment,and the improvements in the observation group were more common(P＜0.05).The indicators of all pulmonary ventilation were significantly elevated compared to those before treatment,and the observation group showed higher levels than the control group(P＜0.05).The chest-lung compliances including thoracic compliance,lung compliance,total compliance were all significantly increased compared to before treatment,with higher compliances in the observation group(P＜0.05).Conclusion Bronchoscopic lavage combined with methylprednisolone sodium succinate and routine treatments have a beneficial effect on improving inflammatory response,chest-lung compliance,immune function,and pulmonary ventilation levels in patients with RMPP,with a good effect.
Keywords：methylprednisolone sodium succinatebronchoscopic lavagerefractory mycoplasma pneumoniae pneumoniaserum inflammatory factorchest-lung complianceimmune functionpulmonary ventilation
Publication Date：2025-06-26
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 930-933,938 )