Value of apparent diffusion coefficient histogram parameters in predicting preoperative stage of ovarian cancer and its correlation with Ki-67 expression
LIU Yang
XIE Ziteng
LI Guanxiong
Abstract：Objective To explore the diagnostic value of apparent diffusion coefficient(ADC)histogram parameters in predicting preoperative stage of ovarian cancer and its correlation with Ki-67 expression.Methods The preoperative magnetic resonance imaging(MRI)and clinical data including age,International Federation of Gynecology and Obstetrics(FIGO)stage,Ki-67 expression of 65 patients with a confirmed diagnosis of primary ovarian cancer on the basis of surgical pathology results were analyzed retrospectively.ADC histogram parameters were calculated by MaZda software,aiming to compare the differences in parameters between FIGO Ⅰ-Ⅳ stages.According to relevant literature classification methods,classified stage Ⅰ cancers was as early-stage cancers and stage Ⅱ-Ⅳ cancers as advanced-stage cancers.Receiver operating characteristic(ROC)curve was drawn to evaluate the predictive effect of ADC histogram parameters on early-stage cancers,the correlations between ADC histogram parameters and Ki-67 expression were evaluated.Results ADC histogram parameters decreased with increasing ovarian cancer stage.The mean,1st percentile,10th percentile were significantly higher in stage Ⅰ than in stages Ⅱ,Ⅲ and Ⅳ(P＜0.05),however,there were no significant differences among stages Ⅱ,Ⅲ andⅣ(P＞0.05).The mean,1st percentile and 10th percentile were effective in predicting early-stage cancers,and 1st percentile was associated with the highest AUC(0.811).When 1st percentile ≥ 0.849 × 10-3mm2/s,the sensitivity was 76.0％and the specificity was 83.3％.There were significant negative correlations between the mean,1st percentile,10th percentile and Ki-67 expression.Conclusion ADC histogram parameters contribute to the preoperative differentiation of early and advanced ovarian cancer,with a closely related to Ki-67 expression.
Keywords：ovarian cancerneoplasm stagingKi-67histogram
Publication Date：2025-03-26
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 411-414,419 )