The expressions and clinical prognostic values of HDAC7 and FGF18 in non-small cell lung cancer tissues
WANG Yuhu
XIN Huan
Abstract：Objective To investigate the expressions of histone deacetylase 7(HDACS7)and fibroblast growth factor 18(FGF18)in non-small cell lung cancer(NSCLC)tissues and their prognostic values.Methods A total of 98 NSCLC patients treated in our hospital from June 2018 to June 2020 were selected.Immunohistochemistry was used to detect the expressions of HDAC7 and FGF18 in lung tissues.Spearman rank correlation analysis was used to analyze the correlation between HDAC7 and FGF18 expressions in NSCLC specimens.Kaplan-Meier survival curves and log-rank test were applied to evaluate the influence of HDAC7 and FGF18 on the prognosis of NSCLC patients.Multivariate COX regression analysis was performed to identify the influencing factors for the prognosis of NSCLC.Results The positive rates of HDAC7(65.31％vs 6.12％,x2=74.756,P＜0.001)and FGF18(63.27％vs 8.16％,x2=64.800,P＜0.001)in NSCLC specimens were significantly higher than those of adjacent normal tissues.The expressions of HDAC7 and FGF18 in NSCLC specimens showed a significant positive correlation(r=0.714,P=0.000).The positive rates of HDAC7 and FGF18 in NSCLC specimens with low differentiation,lymph node metastasis,and tumor-node-metastasis(TNM)staging Ⅲ were significantly higher than those with high and medium differentiation,no lymph node metastasis,and TNM staging Ⅰ-Ⅱ(P＜0.05).The 3-year cumulative survival rate of HDAC7-positive NSCLC patients was significantly lower than that of negative patients(Log Rank x2=16.300,P=0.000).The 3-year cumulative survival rate of FGF18-positive NSCLC patients was significantly lower than that of negative patients(Log Rank x2=15.870,P=0.000).Positive expressions of HDAC7 and FGF18,low differentiation,lymph node metastasis,and TNM staging Ⅲ were independent risk factors for the prognosis of NSCLC patients.Conclusion HDAC7 and FGF18 are overexpressed in NSCLC,which are associated with adverse clinical and pathological characteristics and prognosis,serving as novel prognostic markers for NSCLC.
Keywords：non-small cell lung cancerhistone deacetylase 7fibroblast growth factor 18prognosis
Publication Date：2025-02-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 228-231,236 )