Effect of negative pressure therapy plus epidermal growth factor on the recovery of deep and extensive burn patients
JIA Hongfei
LI Maoqing
GAO Xuepo
Abstract：Objective To analyze the effect of negative pressure therapy plus epidermal growth factor on the recovery of deep and extensive burn patients.Methods A total of 100 patients with deep and extensive burns admitted from January 2021 to January 2023 were recruited and randomly divided into the control group and observation group,with 50 patients in each group.Patients in the control group received epidermal growth factor+nursing intervention,while those in the observation group received negative pressure treatment+epidermal growth factor+nursing intervention.The inflammatory factors,matrix metalloproteinase(MMP)levels,wound healing,severity of pain,and Vancouver Scar Scale(VSS)score were compared between the two groups.Results After treatment,the levels of intercellular adhesion molecule-1(ICAM-1),tumor necrosis factor-a(TNF-a),matrix metalloproteinase-2(MMP-2)and matrix metalloproteinase-9(MMP-9)significantly decreased,and the levels of interleukin-10(IL-10)significantly increased in both groups,which were more pronounced in the observation group(P＜0.05).Compared with the control group,the observation group had significantly shorter healing time and lower VSS score(P＜0.05).Compared with data on 7 days after treatment,significantly higher wound healing rate and lower Numerical Rating Scale(NRS)score on 14 and 21 days were detected in both groups,which were more pronounced in the observation group(P＜0.05).Compared with data on 14 days after treatment,significantly higher wound healing rate and lower NRS score on 21 days were detected in both groups,which were more pronounced in the observation group(P＜0.05).Conclusion Negative pressure treatment plus epidermal growth factor treatment effectively reduces the inflammatory reaction and pain,and accelerates the wound healing speed in patients with deep and extensive burn.
Keywords：deep and extensive burnsnegative pressure therapyepidermal growth factorwound healinginflammatory response
Publication Date：2024-12-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 3601-3604,3608 )