Expression and clinical significance of LncRNA HCG22 in skin squamous cell carcinoma tissues and cells
CAI Man
LIU Yingchun
LI Bing
Abstract：Objective This article aims to study the serum expression of human leukocyte antigen complex group 22(HCG22)of patients with skin squamous cell carcinoma(SSCC),and to explore its clinical value for the diagnosis of cervical cancer(CC)and the prediction of high-risk human papillomavirus(HR-HPV)infection.Methods A total of 125 patients with SSCC admitted from December 2018 to February 2021 were enrolled in this study,including 78 patients with HR-HPV.In the meantime,76 healthy people were selected as controls.The serum expression of HCG22 in the subjects was detected by real-time quantitative reverse transcription polymerase chain reaction(RT-qPCR),and the diagnostic efficacy of HCG22 in SSCC was analyzed by receiver operating characteristic(ROC)curve.SSCC patients were divided into HCG22 low expression group and high expression group based on the median value of HCG22 serum expression.The association between HCG22 serum expression and clinical indicators,between HCG22 serum expression and pathological indexes in SSCC patients was analyzed.Logistics multivariate regression was used to analyze whether HCG22 was independently associated with HR-HPV infection in SSCC.Results Compared with healthy subjects,the serum expression of HCG22 in SSCC patients was significantly lower,the area under the ROC curve(AUC)for diagnosing SSCC was 0.9394,with 0.3850 of the cut-off value,88.18％of the sensitivity,and 92.00％of the specificity.The serum expression of HCG22 in SSCC patients with positive HR-HPV was significantly higher than that of SSCC patients with negative HR-HPV.The AUC of HCG22 for diagnosing SSCC in HR-HPV positive,cutoff value,sensitivity,and specificity was 0.7381,0.3150,83.33％,and 68.09％,respectively.The serum expression of HCG22 was significantly correlated with clinical stage,tumor differentiation,lymph node metastasis,depth of muscle-invasion,and HR-HPV infection,and HCG22 was independently correlated with HR-HPV infection in SSCC.Conclusion HCG22 is lowly serum expression in the SSCC patients with HR-HPV,which is independently correlated with HR-HPV infection in SSCC,with a certain auxiliary diagnostic value for HR-HPV infection in SSCC
Keywords：skin squamous cell carcinomahigh-risk human papillomavirus(HR-HPV)human leukocyte antigen complex group 22(HCG22)receiver operating characteristic(ROC)Logistic regression
Publication Date：2024-12-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 3529-3533 )