Expression level of oncostatin M in diabetic osteoporosis and its clinical significance
YUN Jing
LIU Changlu
Abstract：Objective To observe the expression changes of oncostatin M(OSM)in patients with diabetic osteoporosis,and to analyze its relationship with bone metabolism and bone turnover parameters.Moreover,to explore the role of OSM in the occurrence and development of diabetic osteoporosis.Methods A total of 113 patients with type 2 diabetes mellitus(T2DM)admitted to our hospital from July 2021 to July 2023 were selected.According to the diagnostic criteria of osteoporosis,they were divided into normal bone mass group(28 cases),osteopenia group(39 cases)and osteoporosis group(46 cases).General data of patients were collected.Biochemical,bone metabolism and bone turnover parameters,as well as serum OSM levels were determined.The correlation of serum OSM level with bone mineral density(BMD),bone metabolism and bone turnover was analyzed.The influencing factors of diabetic osteoporosis were analyzed by Logistic regression.Results There were significant differences in body mass index(BMI),glycosylated hemoglobin(HbAlc),25-hydroxyvitamin D3(25(OH)D3),parathyroid hormone(PTH),osteocalcin,N-terminal propeptide of type Ⅰ procollagen(PINP),β-carboxy-terminal cross-linking telopeptide of type Ⅰ collagen(β-CTX)and bone mineral density(BMD)among the three groups(P＜0.05).The OSM level of osteoporosis group and osteopenia group was significantly lower than that of normal bone mass group,and it was significantly lower in osteoporosis group than that of osteopenia group(P＜0.05).Serum OSM level was positively correlated with 25(OH)D3,osteocalcin,PINP and BMD,but negatively correlated with PTH and β-CTX(P＜0.05).Logistic regression analysis showed that BMI,PINP,OSM and β-CTX were the influencing factors of diabetic osteoporosis(P＜0.05).Conclusion The change of OSM level is closely related to the occurrence of diabetic osteoporosis,and OSM level is a protective factor for osteoporosis in T2DM patients.
Keywords：oncostatin Mdiabetic osteoporosisbone metabolism
Publication Date：2024-11-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 3246-3249 )