Target-controlled infusion of sufentanil combined with propofol in liver cancer patients treated with laparoscopic radical hepatectomy
WANG Chengjun
PAN Wei
JIANG Chaoyang
Abstract：Objective To study the effect of target-controlled infusion of sufentanil combined with propofol on hepatic ischemia-reperfusion injury and neurological function in liver cancer patients treated with laparoscopic radical hepatectomy.Methods A total of 66 liver cancer patients treated with an elective laparoscopic radical hepatectomy from January 2019 to 2023 September were selected and randomly divided into the observation group(33 cases)and control group(33 cases).Target-controlled infusion of sufentanil combined with propofol,and constant injection of sufentanil combined with target-controlled infusion of propofol were performed in patients of the observation group and control group,respectively.The inflammatory stress reaction,oxidative stress reaction,hepatic ischemia-reperfusion injury,neurological function and adverse events were compared between two groups at different time points.Results At 1 h of anesthesia(T1),24 h of surgery(T2),and 72 h of surgery(T3),C-reactive protein(CRP),interleukin 6(IL-6)and tumor necrosis factor alpha(TNF-α)were significantly lower in the observation group than those of the control group(P＜0.05).Malondialdehyde(MDA)and cortisol(Cor)were significantly lower in the observation group than those of the control group,and superoxide dismutase(SOD)was significantly higher(P＜0.05).Alanine transaminase(ALT)and aspartate transaminase(AST)were significantly lower in the observation group than those of the control group(P＜0.05).Nerve growth factor(NGF)was significantly higher than that of the control group,and S100 calcium-binding protein B(S100β)and neuron-specific enolase(NSE)were significantly lower(P＜0.05).The total incidence of adverse events in the observation group was significantly lower than that of the control group(12.12％vs 36.36％,X2=5.280,P＜0.05).Conclusion Target-controlled infusion of sufentanil combined with propofol can alleviate hepatic ischemia-reperfusion injury and neurological impairment in liver cancer patients with laparoscopic radical hepatectomy by inhibiting inflammatory stress and oxidative stress.
Keywords：radical hepatectomysufentanilpropofoltarget-controlled infusionstress reactionischemia-reperfusion injuryneurological function
Publication Date：2024-11-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 3232-3236,3241 )