Diagnostic value of multimodal MRI combined with serum STIP1 and YKL-40 levels for breast cancer

ZHANG Xiang; WANG Rongzhou; CUI Wenjing

doi:10.3969/j.issn.1002-7386.2024.20.007

Abstract：Objective To explore the diagnostic value of multimodal magnetic resonance imaging(MRI)combined with serum stress-induced phosphoprotein 1(STIP1)and chitinase protein 40(YKL-40)levels for breast cancer.Methods From August 2021 to July 2023,76 female patients with breast cancer were regarded as the breast cancer group,and 76 patients with benign breast lesions confirmed by pathological examination were included as the benign group.Serum STIP1 and YKL-40 levels,and multimodal MRI findings were compared between the two groups.The consistency test(Kappa value)was applied to compare the consistency of multimodal MRI,serum STIP1,and YKL-40 and their combination in the diagnosis of breast cancer with pathological results.The receiver operating characteristic(ROC)curves were plotted to analyze the diagnostic value of serum STIP1 and YKL-40 levels and multimodal MRI for breast cancer.Results Serum STIP1 and YKL-40 levels in breast cancer group were significantly higher than those of benign group(P＜0.05).A total of 69 patients with breast cancer was diagnosed by the combined detection of multimodal MRI,serum STIP1,and serum YKL-40,showing a high consistency with the pathological diagnosis(Kappa value=0.803,P＜0.05).The positive predictive value,negative predictive value,accuracy,sensitivity and specificity of the combined diagnosis was 89.61％,90.67％,90.13％,90.79％,and 89.47％,respectively,all of which were significantly higher than that of an individual examination for diagnosis(P＜0.05).ROC analysis showed that the area under the curve(AUC)of the combined diagnosis was 0.922(95％CI:0.883-0.961),which was higher than that of an individual diagnosis(Z combination-STIP 1=4.318,Zcombination-YKL-40=2.720,Z combination-multimodal MRI=3.171,all P＜0.05).Conclusion Serum STIP1 and YKL-40 levels elevate in breast cancer patients.The combination of STIP1 and YKL-40 with multimodal MRI is effective in the diagnosis of breast cancer.