Predictive value of des-gamma-carboxy prothrombin in the recurrent metastasis after transarterial chemoembolization of primary liver cancer

WANG Yali; ZHENG Mao; GUO JI Niuniu

doi:10.3969/j.issn.1002-7386.2024.20.006

Abstract：Objective To investigate the predictive value of des-gamma-carboxy prothrombin(DCP)in the recurrent metastasis after transarterial chemoembolization(TACE)in primary liver cancer patients.Methods Totally,clinical data of 150 primary liver cancer patients initially treated with TACE were collected from August 2019 to August 2021 in the Deyang People's Hospital.The risk factors for recurrent metastasis was analyzed by univariate and multivariate Cox regression.The predictive value of serum DCP in the recurrent metastasis of primary liver cancer after TACE was assessed by receiver operating characteristic(ROC)analysis.The tumor-free survival was evaluated by Kaplan-Meier survival analysis.Results Univariate Cox regression showed that age,tumor maximal diameter,tumor number,aspartate transaminase(AST),albumin(ALB),total bilirubin(TBIL),alpha-fetoprotein(AFP),and DCP were significantly associated with recurrent metastasis of primary liver cancer after TACE(all P＜0.05).Multivariate analysis indicated that age,tumor number,TBIL,and DCP were independent risk factors for recurrent metastasis of primary liver cancer after TACE(P＜0.05).The area under the curve(AUC)of DCP in predicting recurrent metastasis of primary liver cancer was 0.782,with the optimal cutoff value of 280.00mAU/mL,specificity of 53.13％and sensitivity of 88.89％.Survival analysis was performed using a DCP cutoff value of 280.00mAU/mL,and the tumor-free survival in the high-level DCP group was significantly lower than that of the low-level DCP group(Log-Rank X2=4.845,P=0.028).Conclusion Serum DCP offers a predictive value recurrent metastasis of primary liver cancer after TACE.Primary liver cancer patients with a pre-TACE serum DCP＞280.00mAU/mL suffer from a high tumor recurrent rate after TACE.