Correlation between pre-pregnancy body mass index and glucose and lipid metabolism indexes and their influences on pregnancy outcome
MA Jingru
HAO Sufang
GAO Ruiping
Abstract：Objective To explore the correlation between pre-pregnancy body mass index(BMI)and glucose and lipid metabolism indexes and their influences on pregnancy outcome.Methods A total of 103 pregnant women who underwent prenatal examination in Shijiazhuang Maternal and Child Health Hospital from January 2021 to December 2021 were recruited and divided into low BMI group(n=13),normal BMI group(n=53),and high BMI group(n=37),the blood lipid metabolism and the occurrence of adverse pregnancy outcomes(APOs)among the three groups were compared.The influencing factors of adverse pregnancy outcomes were analyzed by pregnancy outcomes as the dependent variable,and age,BMI,education level,monthly household income per capita,previous induced abortion,previous pregnancy history,smoking history,drinking history,heavy vaginal bleeding,and intrauterine hematoma as the independent variables.Results Comparison of fasting oral glucose tolerance test(OGTT),1-h OGTT,2-h OGTT,triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C)among three groups:low BMI group＜normal BMI group＜high BMI group.Comparison of high-density lipoprotein cholesterol(HDL-C)among three groups:low BMI group＞normal BMI group＞high BMI group,with statistical significance differences(P＜0.05).The incidence of adverse pregnancy outcomes in the high BMI group(59.46％vs 15.38％,59.46％vs 18.87％)was significantly higher than that in the normal BMI group and the low BMI group(P＜0.05).A total of 34 cases of 103 patients had adverse pregnancy outcomes.After multivariate binary Logistic analysis,normal BMI was a protective factor for adverse pregnancy outcomes(P＜0.05),the heavy vaginal bleeding and intrauterine hematoma were risk factors for adverse pregnancy outcomes(P＜0.05).Conclusion High pre-pregnancy BMI associated with high blood sugar,high TG,TC,LDL-C,and low HDL-C,leading to poor pregnancy outcomes.Maintaining a normal BMI can reduce adverse pregnancy outcomes.Pregnant women with heavy vaginal bleeding and intrauterine hematoma need to take preventive interventions for adverse pregnancy outcomes.
Keywords：body mass indexpregnancyglucose and lipid metabolismpregnancy outcomeinfluencing factors
Publication Date：2024-09-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2809-2812 )