Effect of preventive application of oxycodone at varying doses on the postoperative pain of patients undergoing thoracoscopic surgery
LE Ting
YANG Yong
XIAO Luan
Abstract：Objective To observe the effect of oxycodone at 0.1mg/kg versus 0.15mg/kg on the postoperative pain of patients undergoing thoracoscopic surgery.Methods A total of 80 patients undergoing thoracoscopic surgery from January 2022 to July 2022 were randomly allocated to the observation group(n=40)and the control group(n=40).Patients in both groups were given preventive analgesia 30min before the end of the surgery by intravenous administration of oxycodone at 0.1mg/kg(control group)and 0.15mg/kg(observation group).The Numerical Rating Scale(NRS)scores at 1,6,12 and 24h postoperatively,and the adverse events at 24 h postoperatively were recorded and compared between groups.Results his study included a total of 80 patients who were randomly divided into a control group and an observation group.There was no statistically significant difference in age,gender,and other general information between the two groups(P＞0.05);The difference in relevant biochemical indicators between the observation group and the control group at admission was not statistically significant(P＞0.05);The NRS scores at lh and 6h postoperatively were significantly lower in patients of the observation group than those of control group(P＜0.05),which,at 12h and 24h postoperatively were comparable between groups(P＞0.05).There were no significant differences in the incidence of adverse events and awaking time between groups(P＞0.05).Conclusion A preventive application of oxycodone at 0.15mg/kg effectively alleviates postoperative pain of patients undergoing thoracoscopic surgery without increasing the incidence of adverse events.
Keywords：oxycodonethoracoscopic surgerypreventive analgesia
Publication Date：2024-08-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2477-2480 )