Effect of pre-hospital intravenous thrombolysis on microcirculation perfusion and short-term prognosis in patients with ST-elevation myocardial infarction
AN Qunying
MENG Xianghui
PAN Jiya
Abstract：Objective To evaluate the therapeutic effect of pre-hospital intravenous thrombolysis on microcirculation perfusion and short-term prognosis in patients with ST-elevation myocardial infarction(STEMI)undergoing percutaneous coronary intervention(PCI).Methods STEMI patients admitted from June 2022 to June 2023 were randomly assigned into group A(pre-hospital intravenous thrombolysis,n=58)and group B(PCI after emergency transfer,n=58)according to the reperfusion strategy.Intraoperative conditions,important site bleeding,and major adverse cardiovascular and cerebrovascular events(MACCEs)were compared between the two groups.Results Compared with those of group B,patients in group A presented significantly shorter reperfusion time,more number of patients with preoperative Thrombolysis in Myocardial Infarction(TIMI)of grade 2 and above,less number of stent implants,and lower incidence of non-reperfusion/slow blood flow(P＜0.05).On the 7th,30th,and 90th day after surgery,follow-up echocardiography showed significantly increased left ventricular ejection fraction(LVEF)and decreased left ventricular end-diastolic diameter(LVEDD)and wall motion score index(WMSI)(P＜0.05).There were no significant difference in the incidence of major bleeding events and MACCEs between the two groups(P＞0.05).Conclusion Pre-hospital intravenous thrombolysis effectively shortens the time of myocardial ischemia-reperfusion and reduces the incidence of intraoperative microcirculation perfusion disorders,without increasing the risk of main bleeding events and MACCEs.
Keywords：ST-segment elevation myocardial infarctionPre hospital intravenous thrombolysispercutaneous coronary interventionnon-reperfusion
Publication Date：2024-07-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1950-1954 )