Effect of sivelestat sodium combined with ulinastatin on inflammatory response and blood gas in patients with acute respiratory distress syndrome

WANG Jin; ZHOU Guanhua; WANG Zhuheng

doi:10.3969/j.issn.1002-7386.2024.12.010

Abstract：Objective To detect the effect of sivelestat sodium combined with ulinastatin on inflammatory response and blood gas in patients with acute respiratory distress syndrome(ARDS).Methods A total of 202 ARDS patients admitted in our hospital from May 2021 to March 2023 were enrolled.According to the coin toss methods,patients were assigned into group A(n=101,treatment of ulinastatin)and group B(n=101,treatment of sivelestat sodium combined with ulinastatin).Vital signs(blood pressure,heart rate,body temperature,respiration),inflammatory response(procalcitonin[PCT],lipopolysaccharide[LPS],lysosomal enzyme[LE]),blood gas(oxygenation index[PaO2/FiO2],blood lactic acid[Lac],active carbonic anhydrase[CA]),pulmonary function(dynamic lung compliance[Cdyn],positive end expiration pressure[PEEP],airway resistance[Raw])and adverse events were compared between groups.Results After treatment,significantly decreased heart rate,temperature and respiratory rate,and significantly increased blood pressure were detected in both groups(P＜0.05).No significant differences in the vital signs after treatment were detected between groups(P＞0.05).PCT,LPS,LE,Lac,PEEP and Raw were significantly decreased in both groups after treatment,which were significantly lower in group B than those of Group A(P＜0.05).PaO2/FiO2,CA and Cdyn were significantly increased in both groups after treatment,which were significantly higher in group B than those of Group A(P＜0.05).No significant difference in the incidence of adverse events was detected between groups(P＞0.05).Conclusion Sivelestat sodium combined with ulinastatin offers an excellent therapeutic efficacy on ARDS,which greatly improve vital signs,inflammatory response,blood gas and pulmonary function.