Correlation of lncRNA HOTTIP single nucleotide polymorphism with the occurrence and development of cervical cancer and cervical intraepithelial neoplasia
WANG Chuntao
XIA Chunjun
LIANG Geyu
Abstract：Objective To explore the correlation between long non-coding RNA(LncRNA)HOXA transcript at the distal tip(HOTTIP)rs1859168,rs17427960 single nucleotide polymorphisms(SNPs)with the risk of cervical cancer(CC)and cervical intraepithelial neoplasia(CIN)Methods A total of 14 patients diagnosed as CIN in Yancheng No.1 people's Hospital from November 2019 to May 2021 were included in CIN group,and those diagnosed as CC were included in CC group.During the same period,170 non-cancer non-gynecological disease patients admitted in our hospital were included in control group.Genotyping was performed using the TaqMan-MGB Probe.The correlation of lncRNA HOTTIP SNPs with CC and CIN was detected by Chi-square test and logistic regression analysis.Results There were significant differences in the genotype distributions of lncRNA HOTTIP rs1859168 and rs17427960 between control group and CC group(P＜0.05).In the codominant model,people carrying lncRNA HOTTIP rs1859168 CA(ORadj=1.897,95％CI 1.090-3.300,Padj=0.023)and rs17427960 AC(ORadj=1.787,95％CI 1.020-3.131,Padj=0.042)had a significantly increased risk of CC.In the dominant model,people carrying lncRNA HOTTIP rs1859168 CA+AA(ORadj=1.690,95％CI 1.004-2.844,Padj=0.048)had a significantly increased risk of CC.They were potential susceptible loci for CC.Conclusion HOTTIP rs1859168 and rs17427960 SNPs are associated with the risk of cervical cancer and they can be used as potential susceptibility loci for cervical cancer.
Keywords：cervical cancercervical intraepithelial neoplasiaHOXA transcript at the distal tip(HOTTIP)single nucleotide polymorphismcorrelation study
Publication Date：2024-06-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1765-1770 )