Effect of hysteroscopic cold knife separation combined with estrogen-assisted enhanced recovery after surgery on inflammatory factors of patients with intrauterine adhesions
LI Haiyan
WANG Xiaojing
SHI Lijuan
Abstract：Objective To investigate the effect of hysteroscopic cold knife separation combined with estrogen-assisted enhanced recovery after surgery(ERAS)on inflammatory factors of patients with intrauterine adhesions.Methods A total of 100 patients with intrauterine adhesions admitted from October 2019 to October 2022 were selected as the study subjects.They were randomly divided into the control group(n=50)and the observation group(n=50).Patients in both groups were treated with hysteroscopic cold knife separation combined with estrogen therapy,and those in the observation group were additionally given ERAS-based clinical management.The clinical efficacy at 1 month and 3 months postoperatively was compared.5 mL of fasting venous blood was drawn before and 3 days after operation,and serum samples were obtained by centrifugation.The levels of C-reactive protein(CRP),interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-a)were recorded.The incidence of postoperative complications,including abdominal pain,bleeding and re-adhesion,was calculated.Results The clinical efficacy at 1 month and 3 months postoperatively in the observation group was significantly higher than that of the control group(P＜0.05).CRP and TNF-α levels on 3 days postoperatively in both groups were significantly lower than those before surgery(P＜0.05),while IL-6 and IL-8 levels were significantly higher(P＜0.05).Patients in the observation group had significantly lower CRP and TNF-α levels on 3 days postoperatively,and higher IL-6 and IL-8 levels than those of control group(P＜0.05).The incidence of postoperative complications in the observation group was significantly lower than that of the control group(P＜0.05).Conclusion Hysteroscopic cold knife separation combined with estrogen-assisted ERAS can improve the clinical efficacy,alleviate inflammatory factors and reduce the incidence of postoperative complications compared with hysteroscopic cold knife separation combined with estrogen therapy.
Keywords：hysteroscopycold knife separationestrogenenhanced recovery after surgeryintrauterine adhesionsinflammatory factor
Publication Date：2024-04-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1180-1183 )