Predictive value of thromboelastogram combined with the detection of peripheral blood NSE,CRP and D-dimer in predicting venous thromboembolism events after radical surgery for lung cancer
GUO Ying
HAN Juling
HE Fan
Abstract：Objective To explore the predictive value of thromboelastogram(TEG)combined with the detection of peripheral blood neuron specific enolase(NSE),C-reactive protein(CRP)and D-dimer(D-D)for predicting venous thromboembolism(VTE)events after radical surgery for lung cancer.Methods A total of 300 patients undergoing radical surgery for lung cancer were enrolled as the research objects between January 2020 and December 2022.According to presence or absence of VTE within 1 month after surgery,they were divided into VTE group(84 cases)and non-VTE group(216 cases).TEG parameters,peripheral blood levels of NSE,CRP and D-D were detected,and their predictive value for VTE was analyzed.Results Compared with those of non-VTE group,the maximum amplitude(MA)and α angle were significantly higher,while K(time taken to achieve a certain level of clot strength)and R(time of latency from start of test to initial fibrin formation)were significantly lower in VTE group(P<0.05).Compared with those of non-VTE group,peripheral blood levels of NSE,CRP and D-D were significantly higher in VTE group(P<0.05).The receiver operating characteristic(ROC)curves showed that the area under the curve(AUC)of MA,K,R,α,NSE,CRP and D-D for predicting VTE after radical surgery for lung cancer were 0.762,0.787,0.682,0.775,0.716,0.786 and 0.818,respectively,with the cut-off values of 78.52mm,2.27min,5.30min,82.25°,15.94μg/L,20.12mg/L and 3.64mg/L,respectively.The AUC of the combined detection of the six indexes was 0.968,which was significantly larger than that of a single detection(P<0.05).Conclusion TEG parameters combined with the detection of peripheral blood NSE,CRP and D-D have high a predictive value for VTE events after radical surgery for lung cancer.
Keywords：thromboelastogramneuron specific enolaseC-reactive proteinD-dimerradical surgery for lung cancervenous thromboembolism
Publication Date：2023-12-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 3764-3767 )