The diagnostic value of detection of human epididymal protein 4, carcinoembryonic antigen,carbohydrate antigens in diagnosis of ovarian cancer
Abstract：Objective To explore the clinical value of tumor markers including HE4,CEA,CA125 and CA199 in early diagnosis of ovarian cancer. Methods A total of 120 patients with ovarian cancer were enrolled as ovarian cancer group, 112 patients with benign ovarian lesion were enrolled as benign ovarian lesion group,and 108 healthy subjects who underwent ? physical examinees? were served as control group. The levels of tumor markers of the three groups, the difference of the indexes at different stages were observed and compared among the three groups. Results There were significant differences in the levels of HE4,CEA,CA125 and CA199 among the three groups (P<0. 05), in which, the levels of HE4, CEA, CA125 and CA199 of patients with ovarian cancer at stage Ⅲ~Ⅳwere significantly higher than those at stageⅠ~Ⅱ(P<0. 05). Moreover, the sensitivity, Jorden index and negative predictive value of combined detection were 95. 00% ,0. 70,96. 51% , respectively,which were significantly higher than those by single index detection. The highest AUC in single index detection was HE4 (0. 912), and the lowest one was CA199 (0. 681). AUC of combination detection was 0. 951. Conclusion The detection of HE4,CEA,CA125 and CA199 is helpful to diagnose early ovarian cancer,moreover,the combination detection of these indexes is superior to the single index detection.
Keywords：human epididymal protein 4carcinoembryonic antigenCA125CA199ovarian cancerearly diagnosis
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2155-2157,2162 )