Clinical efficacy of Kuntai capsule combined with kunbao pill in treatment of perimenopausal period cardiovascular disease

doi:10.3969/j.issn.1002-7386.2018.14.008

Abstract：Objective To investigate the clinical efficacy of integrated traditional Chinese and western medicine in treatment of perimenopausal period cardiovascular disease. Methods One hundred patients with perimenopausal period cardiovascular diseases who were diagnosed and treated in our hospital were randomly divided into experimental group and control group,with 50 cases in each group. The patients in control group were treated by oral estradiol valerate,however,the patients in experimental group,on the basis of control group,were treated by Kuntai capsule and Kunbao pills. The Kupperman menopause indexes (KMI),glycosylated hemoglobin (HbA1c),high sensitive C reactive protein (hs-CRP),body mass index ( BMI),insulin resistance index (HOMA-IR),systolic blood pressure and serum low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C),apolipoprotein A1 (ApoA1),lipoprotein (a) Lp (a)]before and after treatment as well as the adverse reactions during treatment were observed and compared between the two groups. Results After treatment,KMI ,hot flashes sweating, anxiety, irritability, insomnia and amnesia scores were significantly decreased in both groups,as compared with those before treatment (P<0. 05),the decrease levels in experimental group were significantly lower than those in control group (P <0. 05). As compared with those before treatment,the hs-CRP levels were significantly decreased in experimental group after treatment (P<0. 05),moreover,which in experimental group were significantly lower than those in control group (P<0. 05). After treatment the BMI,systolic blood pressure levels , serum levels of TC,TG,LDL, HDL,APOA1 and Lp(a) were significantly decreased in both groups, as cdompared with those before treatment (P<0. 05), moreover the levels of these indexes in experimental group were significantly lower than those in control group (P<0. 05). However there were no significant differences in HbA1c and HOMA-IR levels before and after treatment between the two groups (P>0. 05). In addition the incidence rate of nausea and vomiting,vaginal bleeding,breast pain rate in experimental group was 6% ,which was significantly lower than that (18% ) in control group (P<0. 05). Conclusion The combination of traditional Chinese and western medicine in treatment of perimenopausal period cardiovascular disease can effectively relieve the clinical symptoms of patients,improve patient's indexes,decrease incidence of adverse reactions,with higher safety, therefor,which is worth using widely in clinical practice.