Clinical significance of combination detection of HPV with SCCA in screening and prognosis monitoring of cervical cancer

LIU Wanqing; LAI Cengzhen; WEI Qin

doi:10.3969/j.issn.1002-7386.2018.14.005

Abstract：Objective To investigate the clinical significance of combination detection of human papilloma virus ( HPV) with squamous cell carcinoma antigen (SCCA) in screening and prognosis monitoring of cervical cancer. Methods A total of 78 subjects with negative results of cervical cancer screening were enrolled as control group,and the other 92 patients with cervical cancer were enrolled as cervical cancer group. The patients in cervical cancer group were followed up regularly for 3 years after being treated,and the levels of HPV-DNA and plasma SCCA were dynamically monitored. Moreover the cervical cancer group was subdivided into relapse group and the non-relapse group according to the the results of the follow up,and the changes of HPV-DNA and plasma SCCA were observed and compared among groups,finally, the clinical value of combination detection of HPV and plasma SCCA in screening and prognosis monitoring of cervical cancer was analyzed. Results The 40 patients in cervical cancer group had relapse after 3-year treatment ,with the relapse rate being 43. 48% . The positive rate of plasma SCCA in cervical cancer group was 85. 87% ,however,the plasma levels of SCCA in control group were within the normal threshold,there was a significant difference in the SCCA positive rate between cervical cancer group and control group (P<0. 01). The HPV infection rate in cervical cancer group was significantly higher than that in control group (96. 74% vs 1. 28% ,P <0. 01). The SCCA positive rate (92. 50% ) in relapse group was significantly higher than that (1. 92% ) in non-relapse group (P<0. 01). The HPV infection rate in relapse group was significantly higher than that in non-relapse group (95. 00% vs 1. 92% ,P<0. 01). Moreover the area under curve of HPV and SCCA in diagnosis of cervical cancer was 0. 864 and 0. 820,respectively, however,which by combination detection HPV with SCCA was 0. 940. In addition the area under curve of HPV combined with SCCA was 0. 954 in prognosis monitoring of cervical cancer,which was significantly larger than that (0. 851 and 0. 856) by simple detection of HPV or SCCA. Conclusion The HPV infection is main pathogenesis of cervical cancer, and HPV-DNA detection is quite sensitive. The plasma SCCA is important serological marker of cervical cancer,and SCCA detection is very specific. The combination detection of HPV with SCCA has an important clinical value in screening and prognosis monitoring of cervical cancer.