Clinical curative effects of budesonide aerosol inhalation combined with montelukast sodium on asthma in children and their effects on serum levels of CRP, IL-4, IL 6, IL-17, TNF-α of patients
Abstract：Objective To investigate the therapeutic effects of budesonide alevaire aer combined with montelukast sodium on asthma in children and their effects on serum levels of CRP, IL-4, IL 6, IL-17, TNF-α of patients. Methods A total of 98 children patients with asthma who were treated in our hospital from March 2014 to March 2016 were randomly divided into observation group ( n =49 ) and control group ( n =49 ) according to random digital table. The patients in observation group were treated by budesonide aerosol inhalation combined with montelukast sodium,however,the patients in control group were treated only by budesonide aerosol inhalation. The changes of serum levels of CRP, IL-4, IL 6,IL-17, TNF-α before and after treatment were observed and compared between two groups. Results The excellence rate in observation group was 69. 39% (34/49), and total effective rate was 95. 92% (47/49), which were significantly higher than those in control group [48. 98% (24/49), 81. 63% (40/49),respectivly] (P ＜0. 05). Before treatment,there were no siggnificant differences in serum levels of CRP and TNF-alpha between two groups (P＞0. 05). After treatment, the serum levels of CRP and TNF-alpha in observation group were significantly lower than those in control group (P＜0. 05). Before treatment, there were no siggnificant differences in serum levels of IL-4, IL 6 and IL-17 between two groups (P＜0. 05). After treatment, the serum levels of IL-4, IL 6 and IL-17 in observation group were significantly lower than those in control group (P ＜0. 05). Before treatment, there were no siggnificant differences in pulmonary function indexes including FVC, FEV1 and PEF between two groups (P ＞0. 05). After treatment, the FVC, FEV1 and PEF in observation group were significantly higher than those in control group (P＜0. 05). Conclusion The budesonide aerosol inhalation combined with montelukast sodium can obviously improve the curative effects on on asthma in children ,which can also significantly reduce the levels of inflammatory factors and improve the lung function of patients,therefor,which is worth using widely in clinical practice.
Keywords：budesonide aerosolmontelukast sodiumasthma in childrenserum CRPinflammatory factorTNF-α
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1969-1971,1975 )