Effects of enteral nutrition on inflammatory factors and immune function at different opportunities in patients with severe acute pancreatitis
Abstract：Objective To investigate and analyze the effects of enteral nutrition on inflammatory factors and immune function in patients with severe acute pancreatitis at different opportunities. Methods A total of 100 patients with severe acute pancreatitis who were treated in our hospital were enrolled in the study. According to random digital table, these patients were divided into observation group ( n=50) and control group ( n=50). The patients in control group were treated by delayed enteral nutrition,however,the patients in observation group were treated by early enteral nutrition. The general status including gender, age, etiology and complications, CRP (C reactive protein),PCT(procalcitonin),TNF-α ( tumor necrosis factor-α), IL-6 and recovery conditions including disappearing time of abdominal pain and abdominal distension, recovery time of bowel sound, exhaust and defecation, hospitalization time were observed and compared between two groups. Results However there was significant difference in CRP between two groups (P ＜0. 05). With the treatment going on, the CRP levels were decreased in both groups,moreover,the decrease degree in observation group was more obvious than that in control group (P＜0. 05). The repeat analysis of variance showed that there was significant difference in PCT between two groups (P＜0. 05). the PCT levels were decreased in both groups, but the decrease degree in observation group was more obvious than that in control group (P＜0. 05). There were significant differences in levels of TNF-α before and after treatment between two groups (P＜0. 05),the levels of TNF-α were decreased in both groups, but the decrease degree in observation group was remarkably greater than that in control group (P ＜0. 05). Moreover there were significant differences in IL-6 levels before and after treatment between two groups (P＜0. 05),the IL-6 levels were decreased in both groups,however, the decrease degree in observation group was significantly greater than that in control group (P＜0. 05). Besides the disappearing time of abdominal pain and abdominal distension, recovery time of bowel sound, exhaust and defecation, hospitalization time in observation group were significantly shorter than those in control group (P ＜0. 05). Conclusion The early enteral nutrition can effectively improve the inflammatory and immune reactions in patients with severe acute pancreatitis,which can promote the postoperative recovery of patients,thus,which is worth uisng widely in clinical practice.
Keywords：early enteral nutritionsevere acute pancreatitisinflammatory factorsimmune
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1949-1952 )