The application value of ultrasound combined with detection of creatine kinase and AFP in diagnosis and prognosis evaluation of dangerous placenta previa complicated by placenta accreta

doi:10.3969/j.issn.1002-7386.2018.13.004

Abstract：Objective To investigate the application value of ultrasound combined with detection of creatine kinase and alpha-fetoprotein ( AFP) in diagnosis and prognosis evaluation of dangerous placenta previa complicated by placenta accreta. Methods A total of 101 patients with dangerous placenta previa complicated by placenta accreta who were treated in our hospital from January 2014 to December 2016 were enrolled as experimental group,at the same time, the other 101 patients with dangerous placenta previa without placenta accreta were enrolled as control group. The ultrasonic examination combined with creatine kinase detection were performed to observe and compare the differences of examination results between the two groups. The patients in experimental group were treated by preset balloon catheter cesarean section,then according the the therapeutic effects, these patients were redivided into valid group and invalid group, who were examined by ultrasound combined with creatine kinase detection again,the examination results were obseerved and compared between the two groups, the correlation between the examination results and therapeutic effects was analyzed. Results The placenta and uterine muscle layer boundary was not clear in experimental group,with irregular liquid dark area within placenta, placental intraparenchymal lacouna blood flow,placenta severe vascularization,and the ultrasound detection rates of these charecteristics were significantly higher than those in control group (P＜0. 05). Before treatment the serum levels of creatine kinase and AFP in experimental group were significantly higher than those in control group (P＜0. 05). Single factor Logistic regression analysis showed that the maximum likelihood ratio and OR values were all greater than 0 (P ＜0. 05). After treatment the detection rates of endometrial myometrial smooth,clear boundary,normal uterine blood flow,normal uterine size,uterine bladder peritoneal line continuous in valid group were significantly higher than those in invalid group (P＜0. 05). After treatment,the serum levels of creatine kinase and AFP in valid group were significantly lower than those in invalid group (P＜0. 05). Single factor Logistic regression analysis showed that the maximum likelihood ratio and OR value of serum molecules were less than 0 (P＜0. 05). Conclusion Ultrasound combined with creatine kinase and AFP detection can obtain satisfactory effects in diagnosis and prognosis evaluation of dangerous placenta previa complicated by placenta accreta,moreover,the serum levels of creatine kinase are positively correlated with the severity of disease,however,which are negatively correlated with the therapeutic effect.