Detection values of Hcy, HbA1c, U-mAlb in patients with early diabetic kidney injury
LI Hong
Abstract：Objective To explore the detection values of homocysteine ( Hcy ) , glycosylated hemoglobin Alc (HbA1c) and urine microalbumin (U-mAlb) in the patients with early diabetic kidney injury. Methods One hundred patients with type 2 diabetes mellitus were enrolled as observe group,in whom, urine protein was positive in 46 cases and urine protein was negative in 54 cases,moreover 50 healthy volunteers were enrolled as control group. The detection results of Hcy, HbA1c and U mAlb were analyzed and comapred among the three groups, and analyzed the abnormal detection situation that single detection, the combination detection of two indexes or three indexes in patients with different urine protein detection results. Results After treatment the levels of fasting blood glucose (FBG), 2h postprandial blood glucose (2h PBG), HbA1c, Hcy, U-mAlb in observation group were significantly lower than those before treatment (P<0. 05). The levels of FBG, 2h PBG, HbA1c, Hcy, U-mAlb in observation group were significantly higher than those in control group before and after treatment (P<0. 05). The levels of FBG, 2h PBG, HbA1c, Hcy, U-mAlb in patients with positive urine protein were significantly higher than those in patients with positive urine protein (P<0. 05),which in the latter were significantly higher than those in control group (P<0. 05). The abnormal detection rates of HbA1c, Hcy, U-mAlb in patients with positive urine protein were significantly higher than those of patients with negative urine protein (P<0. 05). The abnormal detection rate of combination detection of two indexes and three indexes in positive urine protein group was 100%. The abnormal detection rates of combination detection of two indexes and three indexes were significantly higher than that by single detection of HbA1c, Hcy, U-mAlb, respectively (P<0. 05). The abnormal detection rate (72. 22%) of combination detction of three indexes was the highest. Conclusion The detection of Hcy, HbA1c, U-mAlb can discover early diabetic kidney injury, moreover, combination detection can increase the detection rate of early diabetic kidney injury.
Keywords：early diabetic kidney injuryhomocysteineglycosylated hemoglobinurine microcontent malbumin
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1842-1844,1848 )