Effects of compound Xueshuantong combined with calcium dobesilate on the levels of HIF-1 and SDF-1 in patients with non-proliferative diabetic retinopathy
LIU Peng
ZHOU Qun
ZHANG Yulin
Abstract：Objective To observe the effects of compound Xueshuantong combined with calcium dobesilate on he levels of serum hypoxia-inducible factor-1α ( HIF-1α) and stromal cell-derived factor 1 ( SDF-1 ) in patients with non-proliferative diabetic retinopathy ( NPDR) . Methods Ninety patients with NPDR who were treated in our hospital from January 2015 to December 2016 were divided into observation group (n=45) and control group (n=45) according to random number table. The patients in control group were treated by calcium dobesilate,however,the patients in obervation group,on the basis of control group, were treated by compound Xueshuantong. The therapeutic effects, the hemodynamic parameters including ophthalmic artery ( OA) and central retinal artery ( CRA) ,the levels HIF-1α,SDF-1αand SDF-1βbefore and after treatment were observed and compared between the two groups. Results The total effective rate in observation group was 97. 78%. which was significantly higher than that (80. 00%) in control group (χ2 =5. 513,P <0. 05). There were no significant differences in the levels of PSV,EDV and RI of OA and CRA before treatment between two groups (P>0. 05), however,after treatment the levels of PSV and EDV were significantly increased in both groups (P<0. 01),but the levels of RI were significantly decreased (P<0. 01),moreover,the increase or decrease extent in observation group was more obvious than that in control group (P<0. 01). Before treatment, there were no significant differences in the levels of HIF-1α,SDF-1αand SDF-1βbetween two groups (P>0. 05),however, after treatment,the levels of these indexes were significantly decreased in both groups (P<0. 01),moreover, the decrease extent in observation group was more obvious than that in control group (P<0. 01). Conclusion The compound Xueshuantong combined with calcium dobesilate can obtain obvious therapeutic effects on NPDR, and its action mechanism may be correlated with increase of blood flow of retinal vessels and with the dow-regulation of the levels of HIF-1α,SDF-1αand SDF-1β.
Keywords：compound Xueshuantongcalcium dobesilatenon proliferative diabetic retinopathyhypoxia-inducible factor-1αstromal cell-derived factor 1
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1838-1841 )