Therapeutic effects of reduced glutathione combined with reteplase on acute ST segment elevation myocardial infarction

doi:10.3969/j.issn.1002-7386.2018.12.013

Abstract：Objective To observe the therapeutic effects of reduced glutathione (GSH) combined with reteplase ( rPA) on acute ST segment elevation myocardial infarction ( STEMI) . Methods The patients with STEMI who were treated in our Hospital were enrolled as research subjects,and these patients were randomly divided into rPA treatment group and rPA combined with GSH treatment group (combination treatment group). The serum levels of cardiac troponin I(cTnI), cardiac troponin T(cTnT), creatine kinase isoenzyme(CK-MB) and left ventricular ejection fraction(LVEF) before and 24h after treatment were detected and compared between the two groups. Moreover the changes of serum levels of cTnI, cTnT and CK MB before and after treatment were analyzed by means of independent simple T test, and the LVEF levels before and after treatment were observed and analyzed by means of chi-square test. Results There was no significant difference in vascular recanalization rate between the two groups at 3h, 6h and 12h after thrombolysis (P<0. 05). The serum levels of cTnI, cTnT, CK-MB and LVEF at 24h after treatment were significantly increased in both groups, as compared with those before treatment (P<0. 05). As compared with that in rPA treatment group at 24h after treatment, the increase degree of cTnI, cTnT and CK MB in combination treatment group was smaller,and the increase degree of LVEF was larger (P <0. 05). Moreover the incidence rate of major cardiovascular events ( MACE ) at one month after thrombolysis in combination treatment group was significantly lower than that in rPA treatment group (P<0. 05). Conclusion Reduced GSH combined with rPA in treatment of STEMI can protect the structure and function of myocardial cells better,which has higher clinical application value.