Correlation between CT perfusion parameters and the biochemical detection indexes of renal function as well as tumor markers in patients with renal neoplasms

doi:10.3969/j.issn.1002-7386.2018.11.008

Abstract：Objective To investigate the correlation between CT perfusion parameters and the biochemical detection indexes of renal function as well as tumor markers in patients with renal neoplasms. Methods Thirty-six patients with renal tumors who were admitted and treated in our hospital from March 2012 to February 2017 were enrolled as observation group,at the same time, the other 34 healthy subjects who received physical examination in our hospital were enrolled as control group. The equivalent blood volume ( Equiv BV) , surface permeability ( Ps) , blood flow ( BF) and other CT perfusion parameters were abtained by CT perfusion imaging in both groups. Moreover the biochemical detection indexes including blood urea nitrogen ( BUN) , serum creatinine ( Scr) , total cholesterol ( TC) , triglyceride ( TG) and tumor markers including carcino-embryonic antigen (CEA), carbohydrate antigen 125 (CA125), and cytokeratin 19 fragment (Cyfra211) were detected and compared between two groups, and the correlation between CT perfusion parameters and the biochemical indexes of renal function as well as tumor markers was analyzed by means of Pearson analysis. Results The levels of Equiv BV, Ps and BF in observation group were significantly lower than those in control group (P<0. 05), however the levels of BUN, Scr, TC, TG, CEA, CA125 and Cyfra211 in observation group were significantly higher than those in control group (P <0. 05). The Pearson correlation analysis showed that CT perfusion parameters were negatively correlated with the biochemical markers of renal function including BUN, TC and tumor markers including CEA, CA125 and Cyfra211(P<0. 05), however, there was no close correlation between CT perfusion parameters and the levels of Scr and TG (P >0. 05). Conclusion The CT perfusion parameters of patients with renal tumor are negatively correlated with the biochemical indexes of renal function and expressions of tumor markers,which can be regarded as an auxiliary method to evaluate the renal function of patients with renal tumor and clinical diagnosis of disease.