The levels and significance of serum vascular factors and oxidative stress in patients with severe preeclampsia
WANG Chengshu
CHANG Ruijing
HUANG Xianghua
Abstract：Objective To investigate the role of serum VEGF-A, sFlt-1, MDA and T-AOC in patient with preeclampsia. Methods Twenty-eight woman patients with severe preeclampsia who were hospitalized in our hospital from May to December 2014 were enrolled as preeclampsia group ( group PE) ,at the same time, 20 normal pregnant women were enrolled as control group. The serum levels of VEGF-A and sFlt-1 were detected by enzyme-linked immunosorbent assay ( ELISA) ,and the serum levels of MDA and T-AOC were measured by chemical method. Results As compared with those in control group, the serum levels of VEGF-A were significantly decreased in group PE, however,the serum levels of sFlt-1 were significantly increased in group PE (P<0. 05),moreover the MDA levels in group PE were significantly higher than those in control group,but T-AOC levels were significantly lower than those in control group (P<0. 05). In addition the serum levels of VEGF-A in group PE were positivelt correlated with neonatal birth weight and placental weight (P<0. 05). Conclusion The serum levels of MDA,VEGF-A,sFl-1and T-AOC in patients with preeclampsia are changed significantly,which suggests that dysfunction of vascular factor and oxidative stress are involved in the pathogenesis of preeclampsia.
Keywords：preeclampsiavascular endothelial growth factor Aoxidative stress
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1613-1616,1620 )