Clinical effects of comprehensive surgery therapy after concurrent chemotherapy on local advanced rectal cancer
Abstract：Objective To analyze the clinical effects of comprehensive surgery therapy after concurrent chemotherapy in the treatment of locally advanced rectal cancer. Methods The clinical data of 80 patients with local advanced rectal cancer who were admitted and treated in our hospital from January 2012 to January 2014 were retrospectively analyzed. According to different herapeutic methods,these patients were divided into combined modality therapy group(comprehensive surgery therapy after concurrent chemotherapy,n =40) and direct radical surgery group (surgery treatment group,n =40). The clinical effects,radical resection, sphincter preservation, liver metastasis, local recurrences, adverse reactions, as well as 1-year, 2-year and 3-year survival rate were statistically analyzed and compared between two grousp.Results The total remission rate in combined modality therapy group was 77.5% (31/40), which was significantly higher than that [60.0% (24/40)] in surgery treatment group (P<0.05). The radical resection rate, sphincter preservation rate and 1-year,2-year and 3-year survival rate in combined modality therapy group were significantly higher than those in surgery treatment group (P<0.05). However the liver metastasis rate and local recurrence rate in combined modality therapy group were significantly lower than those in surgery treatment group (P <0.05). Conclusion The therapeutic effects of comprehensive surgery therapy after concurrent chemotherapy on local advanced rectal cancer are superior to those by direct radical surgery.
Keywords：locally advanced rectal cancercomprehensive surgery treatment after concurrent chemotherapytreatment outcome
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1359-1361,1365 )