Correlation between the expression levels of PCDH20, VEGF HE4 proteins and clinicopathological features in patients with lung cancer
MA Rongfen
CHEN Qiuying
LIU Yanfen
Abstract：Objective To explore the correlation between the expression levels of protocadherin 20 (PCDH20), vascular endothelial growth factor (VEGF), human epididymal protein 4 (HE4) and clinicopathological features in patients with lung cancer.Methods A total of 104 tissue specimens that were surgical excised from patients with primary lung cancer were selected as research objects (lung cancer group),in which,15 normal lung tissues surrounding in primary lung cancer were selected as control group. The expression levels of PCDH20 mRNA, VEGF and HE4 protein were detected in both groups.Moreover the positive cells of expressions of PCDH20,VEGF and HE4 proteins in lung cancer tissues were labeled by immunohistochemistry method.Results The expression levels of PCDH20 mRNA in lung cancer group were significantly lower than those in control group (P<0.05),however, the expression levels of VEGF and HE4 proteins were significantly higher than those in control group(P<0.05). There were significant differences in positive expression situation and positive rates of PCDH20,VEGF and HE4 proteins between two groups (P<0.05). However there was no significant difference in positive rate of PCDH20 between different sexes(P>0.05). However there were significant differences in positive expression rates of PCDH20 in different diseased regions, pathological stage, differentiation degree and lymph node metastasis (P <0.05). There were no significant differences in positive expression rates of VEGF protein in different sexes and different diseased regions(P>0.05),but there were significant differences in different pathological stages,differentiation degree and lymphatic node metastasis(P<0.05).The multivariate Logistic regression analysis showed that pathological stage,differentiation degree and lymph node metastasis were the factors influencing expressions of PCDH20 and VEGF proteins,and pathological stage was the factor influencing HE4 protein expression, the differences were statistically significant (P < 0. 05). Conclusion PCDH20,VEGF and HE4 proteins are highly expressed in lung cancer tissues,which is correlated with pathological stage, differentiation degree and lymphocyte metastasis at some extent.
Keywords：lung neoplasmsE-cadherin 20vascular endothelial growth factorhuman epididymal protein 4
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1343-1347 )