Effects of Xuebijing on inflammatory factors, blood biochemical indexes and organ function scores in patients with severe trauma
Abstract：Objective To investigate the effects of Xuebijing on inflammatory factors,blood biochemical indexes and organ function scores in patients with severe trauma. Methods A total of 80 patients with severe trauma were randomly divided into research group(n=40) and control group(n=40). The patients in both groups were treated by ositive surgical debridement,positive liquid resuscitation,controlling infection by antibiotics,positive sedation,analgesia treatment and organ function protection after hospitalization. On this basis, the patients in research group were given Xuebijing 50ml combined with 0.9% sodium chloride solution 100ml by intravenous injection,twice a day,continuely for 7 days,however,the patients in control group were given 0.9% sodium chloride solution 100ml by intravenous injection as placebo. The serum levels of interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α), C reactive protein (CRP), procalcitonin (PCT) and adiponectin (APN) were measured before and after treatment. The serum levels of albumin,liver enzymes and cholinesterase at 5d after treatment were detected and compared between two groups.Moreover the acute physiological and chronic health status scores (APACHE Ⅱ) as well as sequential organ failure score (SOFA) and fatality rate were observed and compared between two groups.Results After treatment the levels of IL-6, TNF-α, CRP and PCT were significantly decreased in both groups, as compared with those before treatment,however,the APN levels were significantly increased,moreover,the increase degree and decrease degree in research group were more significant than those in control group (P<0.05). The serum levels of total protein and albumin after treament were significantly increased in both groups, but the levels of liver enzymes and cholinesterase were significantly decreased,moreover, the increase degree and decrease degree in research group were more significant than those in control group (P<0.05). After treatment, APACHE Ⅱ and SOFA scores in research group were significantly lower than those in control group (P<0.05),in addition, the infection rate, mortality rate and hospitalization time in research group were significantly lower than those in control group (P<0.05).Conclusion Xuebijing injection can effectively inhibit inflammatory factors, obviously alleviate inflammatory injury,increase cholinesterase activity and liver protein synthesis ability, reduce liver injury of patients with severe trauma,which can also reduce the infection rate and mortality,shorten treatment course,therefor, which is worthy of popularization and application.
Keywords：severe casetraumainflammatory responseXuebijingsystemic inflammatory response syndrome
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1331-1335 )